Project Grant R16GM165977
- The National Institute of General Medical Sciences (NIGMS), part of the Department of Health and Human Services National Institutes of Health, awarded the University of Texas at Dallas $435,875 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, Assistance Listing) to investigate how tissue-specific progenitor cell fate is governed by mesenchymal progenitors and sympathetic neurons during adult tissue regeneration. The recipient will use the postnatal mouse...
- The National Heart, Lung, and Blood Institute awarded $194,156 to the University of California, Berkeley on September 30, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the role of transcription factor SNAIL1 in heart regeneration using the fish model Astyanax mexicanus. The research examines why heart regeneration capacity differs dramatically between two morphotypes of Astyanax mexicanus that diverged as recently as 20,000 years ago. Surface-dwelling...
- The National Institutes of Health National Heart Lung and Blood Institute awarded Sanford Burnham Prebys Medical Discovery Institute $1,603,648 on July 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop a single-construct gene therapy for enhanced cardiac repair. The funded research aims to overcome barriers to cardiac reprogramming by creating a gene therapy that simultaneously induces overexpression of cardiac transcription factors MEF2C, GATA4, and TBX5 (MGT)...
- The National Institutes of Health National Heart Lung and Blood Institute awarded Oklahoma State University $552,649 on July 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the role of phosphofructokinase-2 (PFK-2) in promoting cardiomyocyte proliferation and heart regeneration following myocardial injury. The research addresses the inability of adult mammalian hearts to regenerate tissue after injury such as heart attack. Unlike neonatal and some...
- The National Heart, Lung, and Blood Institute awarded The Leland Stanford Junior University $198,728 on March 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the molecular mechanisms of mitochondrial calcium extrusion in ischemic heart disease. The research focuses on TMEM65, an emerging target implicated in mitochondrial sodium-dependent calcium extrusion (MNCX). Ischemia-reperfusion injury damages cardiac tissue partly through aberrant mitochondrial...
- The National Heart, Lung, and Blood Institute awarded The Leland Stanford Junior University $770,000 on April 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to fund research unraveling endothelial-cardiomyocyte crosstalk in cardiomyopathy using an integrated multimodal approach. The research examines molecular mechanisms by which endothelial dysfunction contributes to cardiac dysfunction in cardiomyopathy, focusing on cell-to-cell signaling between endothelial cells...
- The National Heart, Lung, and Blood Institute awarded $1.175 million to Icahn School of Medicine at Mount Sinai on April 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate hemogenic mesoderm heterogeneity, regulation, and function in the developing mammalian hematopoietic system. The research, led by Dr. Sturgeon, delineates the molecular and transcriptional mechanisms by which hemogenic mesoderm gives rise to embryonic hematopoietic programs. The work...
- The National Institute of General Medical Sciences, part of the Department of Health and Human Services, awarded $153,560 to the University of California, Santa Barbara on November 21, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, Assistance Listing). The recipient will conduct physiological, molecular, and bioinformatic experiments to determine the role of circadian rhythms in modulating wound healing and whole-body regeneration, with focus on identifying the...
- The National Heart Lung and Blood Institute awarded the Beckman Research Institute of the City of Hope $813,810 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct research on nucleotide supplementation as a treatment strategy for ischemic heart disease and myocardial infarction. The project investigates the role of nucleotide balance in cardiomyocyte proliferation and aims to apply these findings for cardiac repair using large animal models....
- The National Institute of General Medical Sciences awarded the University of Washington $287,219 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate metabolic reprogramming in vertebrate appendage regeneration. The research examines how animals mobilize biomolecules—nucleotides, proteins, and lipids—to regrow lost appendages, using the frog Xenopus tropicalis as a model organism. The principal investigator's central hypothesis is that...
The National Institute of General Medical Sciences awarded San Jose State University Research Foundation $146,500 on August 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate hormonal constraints limiting mammalian cardiomyocyte cell division and heart regenerative capacity. The research examines how thyroid hormone restricts cardiomyocyte proliferative potential after birth, limiting the heart's regenerative capacity in adult mammals. The project uses cell cycle marker analysis, FUCCI time-lapse imaging, digital holography, and molecular characterization to define how thyroid hormone interferes with cell cycle activity and to test whether postnatal thyroid hormone depletion enhances proliferative responses. The work may establish thyroid hormone status as a modifiable endocrine switch to enhance mammalian heart regenerative capacity. Performance occurs at San Jose, California through April 30, 2030. Over the four-year award period, approximately 40 undergraduates and 4 master's-level graduate students will receive training through the project.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $146.5k | 8/4/26 |