Project Grant R16GM165751
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded the University of Maryland, Baltimore a $249,000 Project Grant on September 22, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to support investigative research through August 31, 2028. This award funds basic biomedical research investigating the molecular mechanisms of endocytosis of the activated B cell receptor (BCR) in both healthy and diseased states. The...
- Federal Grant Award Summary The University of Maryland, College Park received a $391,162 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 10, 2025 through July 31, 2030. This Early-Stage Investigator Maximizing Investigators Research Award (ESI MIRA) funds the Biological Engineering for Advanced Drug Delivery (BEADD) Laboratory to conduct fundamental research on the...
- Federal Grant Award Summary The National Science Foundation (NSF) Directorate for Engineering (CFDA 47.041) awarded $199,934 to the University of Maryland Eastern Shore (UMES) on June 1, 2026, for the development of an impedimetric immunosensor platform designed to characterize phagocytosis in immune cells. The project, which extends through May 31, 2028, will create a compact, label-free biosensing platform that measures electrical impedance changes in phagocytic cells as they recognize,...
- Federal Project Grant Award Summary The University of Maryland, Baltimore received a $686,324 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025 through August 31, 2027. This award funds mechanistic research into E3 ubiquitin ligase function in peroxisomes and mitochondria, with particular focus on the protein MARCH5 and its role in mitochondrial and peroxisomal...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded a $825,000 Project Grant to Massachusetts General Hospital's Research Management Division on August 7, 2025, under the Biomedical Research and Research Training program (CFDA 93.859). The five-year award, scheduled for completion on June 30, 2030, supports investigator-initiated research to dissect the molecular mechanisms by which macrophages regulate stem and progenitor cell quality assurance...
- Federal Project Grant Award Summary The University of Minnesota received a $398,144 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective April 1, 2026 through January 31, 2031. The award funds development of immunocompetent tissue models engineered from human pluripotent stem cells (HPSCs) to replicate tissue-resident macrophage behavior and inflammatory responses. The research...
- This $546,600 Project Grant awarded by the National Science Foundation's (NSF) Integrative Activities program (CFDA 47.083) aims to engineer mesenchymal stem cell-derived exosomes (MSC-EXO) for targeted immunomodulation and enhanced bone repair. The University of Maryland Eastern Shore (UMES), a historically black, 1890 land-grant institution, is the primary awardee. The key objectives of this 3-year project are to: 1) generate engineered exosomes (TEX) for reprogramming macrophages, 2) modify...
- Federal Project Grant Award Summary The University of Massachusetts received a $406,250 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded on August 15, 2025, with a completion date of July 31, 2030. The project, "Advancing Disease Modeling Through Mathematical Frameworks: Leveraging Single-Cell Spatial Data to Uncover Tissue-Specific Pathways and Immune Responses," develops...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded the University of Maryland, College Park $405,390 under the Biomedical Research and Research Training program (CFDA 93.859) for a project grant commencing April 1, 2026, with completion scheduled for January 31, 2031. The research focuses on developing improved force fields—computational descriptions of how biological molecules interact—to enhance molecular simulation accuracy for cellular...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded the University of Maryland, Baltimore a Project Grant totaling $427,625 under the Biomedical Research and Research Training program (CFDA 93.859), effective July 1, 2026, through March 31, 2031. This award funds investigator-initiated basic biomedical research examining the bioinorganic chemistry of zinc finger (ZF) proteins, specifically investigating how hydrogen sulfide (H2S), a gaseous...
The National Institute of General Medical Sciences (NIGMS) awarded the University of Maryland Eastern Shore (UMES) a Project Grant totaling $143,000 under the Biomedical Research and Research Training program (CFDA 93.859) on July 15, 2026, with completion targeted for May 31, 2030. The grant funds research on light-activated immunomodulation and in situ scaffolding to enhance mesenchymal stem cell (MSC) therapy. The research addresses two critical barriers limiting clinical efficacy of human MSCs: immune-mediated rejection of transplanted cells and poor retention and engraftment within injured tissues. The research deliverables include: (1) design, synthesis, and characterization of a BEPA-photocaged hydrogel complex enabling controlled release of immunomodulatory agents and hydrogel formation under light activation, and (2) preclinical evaluation of this platform to demonstrate improved immune-compatible and extracellular matrix-mimetic stem cell engraftment. The proposed light-activated platform is designed to establish a "regenerative niche" that provides both immune compatibility and mechanical support, thereby improving MSC survival, retention, and integration in tissue repair and regeneration applications. This innovative approach combines spatiotemporally controlled local immunomodulation with structural scaffolding under a single light-based stimulus, advancing the foundation for improved MSC-based therapeutic interventions.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $143.0k | 7/15/26 |