The genetics of cannabinoid signaling: an organismal analysis
Active Project Grant Awarded Last action
- Award ID
- R16GM159792
- Recipient
-
Harris-Stowe State University UEI U27FC9RA48L3
- Awarding agency
-
National Institute of General Medical Sciences
National Institutes of Health, Department of Health and Human Services
- Obligated
- $337,988
Award facts
- Assistance listing
- 93.859 Biomedical Research and Research Training
- Completion date 29% complete
- Place of performance
- St. Louis, MO 63103, USA
Award details come from USAspending.gov.
Description
- Abstract
- Statement a 2024 publication in the lancet neurology by DR. Steinmeĵ and collaborators of the global burden of disease journal reviewed the prevalence of nervous system disorders worldwide from 1990-2021. Based on this comprehensive study, IT was estimated that approximately 3 billion people worldwide suffered from neuropsychiatric and neurological disorders on a yearly basis during this time frame. From 2015-2018, adult usage of antidepressants in the united states increased from 10 to 13% (CDC national center for health statistics, 2020). Patients suffering from depression and anxiety are traditionally prescribed selective serotonin reuptake inhibitors (SSRIS) and antipsychotic drugs. Recent clinical studies report that cannabidiol (CBD) also provides relief for these and other mental health disorders. However, the mechanisms of CBD action have yet to be completely resolved. The proposed research seeks to understand the molecular-genetic mechanisms of CBD action. From preliminary studies carried out by undergraduate research trainees and biology majors at harris-stowe state university undergraduate (HSSU), we determined that drosophila is a tractable and ideal model system to uncover conserved molecular-genetic mechanisms of CBD action within neuronal tissues. Drosophila neurotransmitzers (NTS) and their receptor targets are evolutionarily conserved across invertebrate and vertebrate species within tissues of the central and peripheral nervous systems. In addition to receptor- targeted regulation of neuronal responses, a population of noncanonical receptors, unique lipophilic membrane domains, and unknown targets modulate NT and CBD activity within vertebrates and invertebrates. Drosophila does not express CB1 and CB2 receptors, but larvae respond pharmacologically to CBD making this classical model system ideal for further investigation of offsite targets. We hypothesize that additional families of noncanonical CBD-responsive genes, especially those important for maintaining unique populations of phospholipids within membranes of brain tissues, function to regulate neural signaling pathways. These newly identified noncanonical genes will be genetically placed within cell signaling hierarchies to further understand the holistic mechanisms of CBD action. The proposed research will continue to support the mission of the HSSU department of life sciences and college of stem to place HSSU students into competitive professional training programs in medicine and science at the doctoral level towards boosting their success in the stem workforce.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $113,988 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $112,000 | |
| Original award | $112,000 |
Quick answers
Who received award R16GM159792?
R16GM159792 was awarded to Harris-Stowe State University by National Institute of General Medical Sciences (National Institutes of Health) on September 1, 2025.
How much is award R16GM159792 worth?
$337,988 has been obligated on R16GM159792.
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