Project Grant R16GM159691
- The National Institute of Environmental Health Sciences awarded the Board of Regents of the University of Nebraska $1,479,178 on September 9, 2025, under the Environmental Health program (CFDA 93.113) to quantify the release of nano- and microplastics from plastic food containers into water and beverages and assess potential health risks. The project measures the release of nano- and microplastics from reusable plastic cups, single-use water and soft drink bottles, and takeaway coffee cups...
- The National Institute of Environmental Health Sciences awarded the University of New Mexico Health Sciences Center $152,500 on August 15, 2026, under the Environmental Health program (CFDA 93.113) to define dose-response relationships and renal functional impairment from simultaneous exposure to micro- and nano-plastics and arsenic. The research establishes a quantitative framework for how micro- and nano-plastics behave when co-present with arsenic in the body, whether their excretion is...
- The National Heart, Lung, and Blood Institute awarded Louisiana State University Health Sciences Center-Shreveport $111,111 on August 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate mechanisms linking endoplasmic reticulum stress, lipid accumulation, and vascular inflammation in atherosclerosis. The research defines how the NCK1 adaptor protein integrates mechanical and metabolic stress to drive endothelial dysfunction. Aim 1 investigates how NCK1...
- The National Institute of Environmental Health Sciences awarded Oklahoma State University $350,000 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the bioavailability and toxicity of microplastic and cadmium mixtures in the human gastrointestinal system and to develop undergraduate research training in interdisciplinary environmental science. The project examines how environmental weathering and digestive processes affect the sorption...
- The National Institute of Environmental Health Sciences awarded the University of New Mexico Health Sciences Center $167,928 under the Environmental Health Project Grant program (CFDA 93.113) on April 1, 2026. The project investigates lipoprotein-mediated nanoplastic uptake and transport across the placenta. The research addresses how micro and nanoplastics translocate into placental tissue and the role chylomicrons may play in facilitating this process. The working hypothesis posits that...
- Federal Project Grant Award Summary Texas A&M University System Health Science Center received a $2.47 million Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), awarded September 15, 2025, with completion anticipated by September 14, 2029. The award supports mechanistic research investigating phthalate-induced epigenetic regulations in adipose tissues and their role in metabolic dysfunction. The project...
- The National Institute of Environmental Health Sciences awarded New York University $10.907 million on September 15, 2025, under the Environmental Health program (CFDA 93.113) to conduct a translational study on the accumulation of micro- and nanoplastic particles in mammalian tissues. The research investigates inter-tissue accumulation of micro- and nanoplastic particles across the lifespan, including the quantified concentration of these particles within systemic tissues, the role of sex, age,...
- The National Institute of Environmental Health Sciences awarded the University of Cincinnati $698,212 on April 1, 2026, under the Environmental Health program (CFDA 93.113) to investigate the impact of micro- and nanoplastics on cardiac toxicity and heart disease susceptibility. The research addresses mechanisms by which micro- and nanoplastics cause cardiac damage, focusing on mitochondrial dysfunction and oxidative stress in the heart. Preliminary findings show that exposure to micro- and...
- The National Institute of General Medical Sciences awarded the Board of Regents of the University of Nebraska $1,173,748 on July 10, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support Phase 3 of the Nebraska Center for Integrated Biomolecular Communication (NCIBC). NCIBC advances understanding of biomolecular communication pathways that regulate cellular functions and coordinate intercellular actions, with application to disease mechanisms and targeted...
- The National Institute of Environmental Health Sciences awarded Duke University $444,125 on February 17, 2026, under the Environmental Health grant program (CFDA 93.113) to develop an integrated computational and experimental workflow for identifying endocrine-disrupting plastic additives using machine learning. The project pursues two aims. Aim 1 develops novel machine learning models trained on publicly available datasets to predict androgen receptor (AR) and estrogen receptor alpha (ERA)...
The National Institute of General Medical Sciences awarded the University of Nebraska $132,735 on July 27, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the potential effects of a universal plasticizer alkylsulfonic phenyl ester on dyslipidemia and atherosclerosis. The project examines whether the plasticizer, widely used in food packaging, medical tubing, and children's toys, activates the pregnane X receptor and contributes to atherosclerotic development through mechanisms similar to previously identified endocrine-disrupting chemicals. The research builds on preliminary data and animal models showing that PXR activation increases atherosclerotic development in LDLR-deficient and APOE-deficient mouse models, with implications for understanding cardiovascular disease risk from chemical exposure. Performance occurs at the University of Nebraska, Kearney, Nebraska, with a period of performance through May 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $132.7k | 7/27/26 |