Project Grant R16GM159665
- This $412,632 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to advance the biocatalytic synthesis of complex medicinal small molecules. The award, with a performance period from August 1, 2025 to July 31, 2030, will fund the development of computer-aided synthesis planning (CASP) tools to generalize known enzymatic reactions and predict routes for producing...
- This Project Grant award of $501,000.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research by The Regents of the University of California, San Francisco (UCSF) to develop simulation-based models that can more accurately interpret experimental data in structural biology. The goal is to enhance understanding of how macromolecules communicate and interact, which is vital for advancing...
- This federal Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), is funding research to develop novel metal complexes based on abundant first-row metalate species for use as catalysts in biomedical and chemical applications. The $147,025 award to the University of California, Merced will support research efforts in two key areas: 1) Investigating the structural and electronic...
- This Project Grant award from the National Science Foundation (NSF) under the Biological Sciences program (CFDA 47.074) provides $369,297 to San Francisco State University (SFSU) to develop a synthetic transhydrogenation module to enhance the production of valuable chemicals using engineered organisms. The key objectives are to: Elucidate the structural mechanisms underlying the autoregulation of the GltAB-GudB enzyme complex in Bacillus subtilis, which regulates glutamate metabolism and impacts...
- This $224,088 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to develop high-throughput microfluidic technology for studying enzyme function using non-canonical amino acids. The project will leverage the High-Throughput Microfluidic Enzyme Kinetics (HT-MEK) platform developed at Stanford University to enable the parallel expression, purification, and quantitative assay...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of engineered enzymes that can be activated to perform targeted modifications of cellular proteins. The $1,602,000 award to the Dana-Farber Cancer Institute, Inc. (DFCI) will fund research to design and apply novel autoinhibited enzymes that can toggle between inactive and active conformations in response...
- This $616,401 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research on enzyme recruitment and metabolic plasticity. The objective is to use biochemistry, evolution experiments, and -omics methods to investigate how cellular features impact enzyme recruitment, which is a key process enabling the evolution of new metabolic pathways. The research will leverage three...
- This two-year, $200,000 Project Grant from the National Science Foundation's Division of Chemical, Bioengineering, Environmental, and Transport Systems will fund research at the Long Beach Research Foundation to develop multi-activity proteins for improved carbohydrate deconstruction. Specifically, the Foundation will produce and test 85 engineered multi-activity proteins containing two catalytic domains each. These proteins aim to increase biomass conversion for alternative fuels and...
- The National Institute of General Medical Sciences (NIGMS) awarded a $306,872 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Fluid Discovery, Inc., a San Francisco-based biotechnology company, to develop a "Universal Platform for Ultrahigh-Throughput Biocatalyst Evolution with Micro-Mass Spectrometry." The award supports the development of a commercial prototype for Fluid Discovery's novel screening platform, which combines scalable hardware,...
- Regents of the University of California at Riverside was awarded $540,000 under a three-year Project Grant from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049). The grant will support research into developing new biomimetic chemical structures that can mimic the behavior of large biomolecules like enzymes. Specifically, Professor Richard Hooley and his team will work to create self-assembled cage complexes containing rigidly or flexibly positioned...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), will support research to develop enzyme-encapsulated protein frameworks for optimizing cascade biocatalysis. The $134,932 award to California State University, Fresno aims to address two key challenges: understanding how structural factors affect the catalytic efficiency of multi-enzyme assemblies, and improving enzyme stability for long-term biocatalyst reuse. The research will focus on a model glucose-to-pyruvate cascade reaction, testing hypotheses about how the structure, spacing, and spatial arrangement of enzymes within the frameworks impact overall catalytic efficiency. This work has the potential to significantly enhance the performance of multi-enzyme biocatalytic systems for various applications.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $134.9k | 8/4/25 |