Project Grant R16GM154694
- The National Cancer Institute (NCI) awarded a $305,031 Project Grant to Round Table Research, Inc. under the Cancer Treatment Research program (CFDA 93.395) to advance extracellular vesicle (EV) therapy for the treatment of glioblastoma (GBM), an aggressive form of brain cancer. The funded project, conducted in collaboration with researchers at the University of North Carolina-Chapel Hill, seeks to develop engineered tumoricidal EVs derived from induced neural stem cells (iNSCs) as a promising...
- This Project Grant award, in the amount of $1,221,128.00, was provided by the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) to the University of Massachusetts Boston. The funding will support a 3-year research project to investigate the biomechanical and biomolecular properties of large extracellular vesicles (L-EVs), which play important roles in cell-to-cell communication and have potential as disease biomarkers and therapeutic carriers. The research team, with...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), is focused on developing a novel high-throughput, high-content imaging platform for analyzing extracellular vesicles (EVs) at the single-particle level. The $298,999 award to Numentus Technologies Inc. will fund the construction, testing, and application of this platform to detect and characterize EV subpopulations, including...
- This federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), supports the development of extracellular vesicles (EVs) as therapeutic carriers. The $622,000 award, effective August 1, 2024 through July 31, 2027, will enable researchers at The Washington University in St. Louis to engineer endothelial cell-derived EVs to efficiently...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program provides $430,375 over 2 years (9/1/2024 - 8/31/2026) to the Mayo Clinic Jacksonville (a nonprofit organization) to explore the role of extracellular vesicles in mediating communication between glioblastoma (GBM) cells and the tumor microenvironment, specifically within the subventricular...
- This $350,000 federal Project Grant was awarded on September 1, 2025 by the National Science Foundation (CFDA 47.041 Engineering) to Florida State University. The objective is to engineer chimeric antigen receptor (CAR)-associated extracellular vesicles (EVs) derived from induced pluripotent stem cell (iPSC)-derived neutrophils (NEU) that can better target glioblastoma, a type of brain cancer. The project will develop CAR-engineered EVs, introduce potentially toxic cargos, and evaluate their...
- This federal Project Grant award of $300,000.00, awarded by the National Science Foundation (NSF) Engineering program (CFDA 47.041), will fund a collaborative research effort to develop chimeric antigen receptor (CAR)-engineered extracellular vesicles (EVs) derived from induced pluripotent stem cell (iPSC)-derived neutrophils. The objective is to engineer these CAR-associated EVs to possess enhanced targeting ability to glioblastoma, an aggressive type of brain cancer. The research team at...
- This Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences, under the Biological Sciences federal grant program (CFDA 47.074), provides $503,000 to Harvey Mudd College to enhance understanding of extracellular vesicle biogenesis through substrate-associated signals. The research will interrogate factors influencing extracellular vesicle formation and selective cargo packaging in astrocytes. Engineered hydrogel substrates engaging integrins expressed by...
- This Project Grant award of $163,640 from the National Cancer Institute's Cancer Research Manpower program (CFDA 93.398) supports research to develop novel non-viral gene delivery platforms for the treatment of glioblastoma, an aggressive brain cancer. The study aims to investigate the use of brain-penetrating nanoparticles modified to target tumor cells, and to further optimize gene delivery through focused ultrasound treatment. The research is being conducted at the University of Virginia,...
- The National Cancer Institute awarded a $148,500 Project Grant under the Cancer Biology Research Program (CFDA 93.396) to the University of North Texas to evaluate the role of extracellular vesicles in modulating the tumor microenvironment, with a focus on their impact on T cell infiltration and suppression in non-small cell lung cancer (NSCLC) and prostate cancer. The project aims to identify specific subpopulations of tumor-derived extracellular vesicles, such as TGN46+ vesicles, that...
This $155,695 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research at Southern Utah University (SUU) to develop enhanced glioblastoma therapy using engineered extracellular vesicles. The 4-year project, starting on Sep 5, 2025, aims to: 1) determine the ability of bovine milk-derived extracellular vesicles modified with the PEP-1-PHOR21 targeting peptide to cross the blood-brain barrier; 2) evaluate the efficacy of the engineered vesicles loaded with the chemotherapy drug temozolomide in killing glioblastoma cells; and 3) optimize the delivery system for improved therapeutic outcomes. This innovative research seeks to overcome key challenges in glioblastoma treatment by leveraging the natural properties of extracellular vesicles for targeted drug delivery to this aggressive brain cancer.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 9/15/25 | ||
| Not listed | $155.7k | 9/4/25 |