Project Grant R16DK148672
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The University of Texas Southwestern Medical Center $813,299 on August 24, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct basic biomedical research on the regulation of obesity-related inflammation by alpha-melanocyte-stimulating hormone (α-MSH). The research investigates the role of α-MSH in coordinating immune and metabolic responses to inflammatory...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The University of Texas Southwestern Medical Center $694,250 on March 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to explore a novel pathway for ApoB mRNA degradation in regulating VLDL secretion and steatotic liver disease. The recipient will conduct basic biomedical research identifying mechanisms by which the HELZ2 gene regulates hepatic lipid secretion...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The University of Texas Health Science Center at San Antonio $707,781 on May 22, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to identify cell type-specific insulin-responsive quantitative trait loci in human skeletal muscle relevant to type 2 diabetes pathogenesis. The research uses single-nuclei RNA sequencing and assay for transposase-accessible chromatin with...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The University of Texas Southwestern Medical Center $295,649 on September 15, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate adipocyte FGF1 signaling in systemic metabolism. The research examines fibroblast growth factor 1 (FGF1) as a potential lipid-lowering therapeutic target for hyperlipidemia and related metabolic disorders. Preliminary studies...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The University of Chicago $123,000 on June 16, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to characterize adipocyte heterogeneity and response to metabolic stress. The funded research uses single-nucleus RNA sequencing and a humanized mouse model to investigate how diverse stimuli influence white adipocyte development and specification, with emphasis on...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Duke University $790,119 on August 26, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate how memory formation in adipose tissue influences metabolic outcomes in obesity. The project, titled "Establishing Memory in Adipose Tissue Influences Future Metabolic Outcomes in Obesity," examines the mechanisms that drive divergent remodeling of white...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Case Western Reserve University $551,915 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate molecular factors controlling vitamin A uptake homeostasis. The research clarifies the roles of dehydrogenase/reductase 3 (DHRS3) and the transcription factor ISX in vitamin A homeostasis and their implications for lipid metabolism through three...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Leland Stanford Junior University $782,886 on February 18, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to support research on obesity control through an appetite-suppressing peptide. The research addresses the urgent need for new metabolies, including obesity and associated metabolic disorders. Work is performed in Palo Alto, California with a period of...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Arkansas for Medical Sciences $717,457 on February 15, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate metabolic rewiring of T cells and the pathogenic connection between diabetes and hypertension. The research examines immune-metabolic crosstalk in the progression from type 2 diabetes to hypertension using a high-fat diet-induced...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded $2,546,148 to the University of Texas Health Science Center at Houston on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate tissue-specific circadian function and the mechanism of retinoid acid receptor-related orphan receptors (RORs). The recipient will conduct basic research on ROR subfamily nuclear receptors that function as core circadian...
The National Institute of Diabetes and Digestive and Kidney Diseases awarded Texas Woman's University $133,175 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the role of DHRS9 in diet-induced obesity and diabetes. The research project will define how DHRS9 modulates insulin sensitivity under high-fat diet conditions across sexes and determine whether retinoid or specialized pro-resolving mediator (SPM) metabolism represents the dominant DHRS9-regulated target. The principal investigator will feed wild-type and DHRS9 knockout mice on high-fat vitamin-A-defined diets and rescue these mice with all-trans retinoic acid or SPMs. The work will characterize insulin signaling and metabolic pathways alongside vitamin A metabolites and SPMs to elucidate the crosstalk between vitamin A metabolism and omega-3 fatty acid-derived SPMs in obesity and insulin resistance pathology. Work is performed in Texas. The project period extends from September 1, 2026, through May 31, 2030. This is a project grant, the standard assistance type for NIH research awards to institutions and individuals proposing to establish, expand, and improve research activities in health sciences.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $133.2k | 9/1/26 |