Project Grant R16AI201106
- The National Institute of Allergy and Infectious Diseases awarded The University Corporation $147,500 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct a multi-scale study of antimicrobial peptide action in non-standard bacterial growth states. The project addresses how antimicrobial peptides (AMPs)—immune-derived molecules that kill bacteria by disrupting membranes and modulate host immune responses—perform under physiologically relevant...
- The National Institute of Allergy and Infectious Diseases awarded University of California, Los Angeles $459,971 on August 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on mucosal IgA induction and spatiotemporal regulation of the microbiome. The research examines how immunoglobulin A antibodies produced in the intestine regulate the human gut microbiome in the absence of infection. The work investigates how IgA anchors bacterial...
- The National Institute of Allergy and Infectious Diseases awarded $433,125 to the Regents of the University of California at Riverside on July 20, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop genetic systems for manipulation and targeted isolation of human gut microbes. The funded research constructs novel shuttle vectors to enable genetic manipulation of cultured gut microbial species and aid in efficient isolation of slow-growing, recalcitrant...
- The National Institute of Allergy and Infectious Diseases awarded The Regents of the University of California, San Francisco $825,786 on July 24, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate how diet-mediated gut microbiome interactions influence early-life susceptibility to respiratory infection and childhood asthma risk. The research project, titled "Determining Diet by Microbiome Interactions That Mitigate Early Life Susceptibility to...
- The National Institute of Allergy and Infectious Diseases awarded the University of Vermont $230,250 on July 7, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate modulation of central nervous system autoimmunity by Akkermansia muciniphila vitamin K metabolism. The research examines the relationship between Akkermansia muciniphila abundance, vitamin K production, and multiple sclerosis disease progression. Preliminary longitudinal analysis in people...
- The National Institute of Allergy and Infectious Diseases awarded New York University $1,694,434 on June 5, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on dietary and microbial strategies that suppress antibiotic-induced antimicrobial resistance in the gut microbiome. The project will systematically identify specific meals and dietary components that either alleviate or worsen antibiotic-induced microbiome damage, using advanced Bayesian...
- The National Institute of Allergy and Infectious Diseases awarded The Regents of the University of California, San Francisco $205,000 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate synergistic effects of dietary interventions and probiotics on gut-lung immune modulation. The project explores how fiber-rich diet combined with intermittent fasting and probiotic strategies can attenuate sterile lung injury. Research Aim 1 tests...
- The National Institute of Allergy and Infectious Diseases awarded the University of California Irvine $141,712 on February 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to characterize a novel histidine phosphotransfer system involved in the virulence of Mycobacterium tuberculosis. The funded research investigates how virulence-associated dikinase (VADK) coordinates metabolism and virulence in MTB by interacting with partner proteins. The work combines...
- The National Institute of Allergy and Infectious Diseases, a component of the Department of Health and Human Services National Institutes of Health, awarded the Regents of the University of California, doing business as University of California, Berkeley, $240,750 on August 20, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The recipient will develop computational and experimental methods to track plasmid dynamics in the human gut microbiome in response to...
- The National Institute of Allergy and Infectious Diseases awarded the University of California, Los Angeles $575,966 on July 13, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate how surface sensing and second messenger signal dynamics control biofilm formation in Pseudomonas aeruginosa. The research tests the central hypothesis that surface sensing signals are transduced into multigenerational cAMP and cyclic-di-guanosine monophosphate (cdGMP)...
The National Institute of Allergy and Infectious Diseases awarded The University Corporation $147,500 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The recipient will conduct research to define the genomic and metabolic determinants by which select Akkermansia species and strains degrade non-fucosylated core human milk oligosaccharides (HMOs) during growth, and to identify ecological interactions among Akkermansia and other HMO-degrading bacteria of the infant gut microbiota. Akkermansia muciniphila is a mucin-degrading bacterium common to the human gut shown to positively impact human health, but the genus is diverse and lacks clear understanding of how this diversity impacts physiological activity and ecological dynamics across the lineage. The research aims to support the long-term goal of developing targeted therapeutic uses of Akkermansia through either stimulating endogenous strains with dietary interventions or administering species as probiotics. The proposed studies will inform strategies to stimulate or administer Akkermansia throughout human life, including in adults through prebiotic dietary formulations. The University Corporation is a non-profit auxiliary organization of California State University, Northridge, based in Northridge, California. The award covers the period September 1, 2026, through August 31, 2030, with performance in Northridge, CA.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $147.5k | 8/31/26 |