Project Grant R16AI189394
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant titled "Role of Tryptophan Catabolism and AHR Pathways in Natural Resistance of Leishmania (Viannia) panamensis to Antimonial Drug" to the University of Maryland, College Park on September 24, 2025. The $193,733 award supports research to investigate the resistance of the Leishmania (Viannia) panamensis parasite, a major cause of cutaneous leishmaniasis in Colombia, to antimonial drugs. The...
- This $570,760 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The grant supports a multidisciplinary research project to study the structure and function of intraflagellar transport (IFT) in the trypanosomatid parasite Leishmania, which causes several major human diseases. The research aims to elucidate the conserved and parasite-specific features of Leishmania...
- This $1,174,636 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855) supports the development of next-generation ELQ compounds for the treatment and prevention of malaria. The research aims to identify novel, rapidly acting anti-malarial drugs to target the blood and liver stages of the Plasmodium falciparum parasite, as well as formulations suitable for long-acting...
- This federal Project Grant award of $791,864 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to identify molecular factors controlling chromatin organization and gene regulation in the malaria parasite Plasmodium falciparum. The research aims to elucidate the importance of long non-coding RNAs (lncRNAs) in parasite development, virulence, and sexual differentiation, with the goal...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $230,808 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Washington University in St. Louis, Missouri. The funding will support research to identify heme-binding proteins in the malaria parasite Plasmodium falciparum and investigate their role in maintaining heme homeostasis. The project aims to better understand how the parasite detoxifies heme, an essential but redox-active...
- This $438,500 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) will support the development of new tools to facilitate drug discovery for proteasomes in parasitic diseases associated with poverty, including neglected tropical diseases (NTDs). The key objectives are to address two key bottlenecks in advancing parasite proteasome research: 1) the time-consuming and limited purification of native parasite 20S...
- This $412,581 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research to define the roles of specialized mitochondrial DNA polymerases (POLIB and POLID) in the replication and maintenance of the complex kinetoplast DNA network of African trypanosomes. These parasites cause neglected tropical diseases such as human African trypanosomiasis, Chagas disease,...
- This $147,656 federal Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to understand the role of transmembrane proteins in the cell division process of the malaria parasite Plasmodium falciparum. The award, effective January 22, 2025 through October 31, 2027, will enable the integration of biochemical and super-resolution microscopy approaches to decipher...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $777,360 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Washington University to advance research on lymphatic filariasis (LF) elimination. The project aims to leverage genomic epidemiology to monitor the number of reproductively active adult parasites, differentiate new and established maternal parasite lineages, and understand the drivers of LF resurgence in areas that...
- The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), awarded a $239,250 Project Grant to Brown University to investigate life-cycle transitions in trypanosomatid parasites using live-cell imaging. The 2-year project, running from August 2025 to July 2027, will leverage a novel agarose microwell confinement strategy to observe cellular processes like cell division in these important human...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $130,000.00 to Fort Lewis College for a project titled "Using Natural Products to Decipher Essential Host-Parasite Interactions in Visceral Leishmaniasis." The goal is to identify the mechanisms of action of sulforaphane, a natural compound, to inhibit the replication of Leishmania parasites within host cells. The project aims to elucidate how Leishmania alters host immune cell responses and determine if sulforaphane can modify these host-parasite interactions to reduce intracellular parasite levels. This 4-year project, starting on September 10, 2025, engages a diverse group of undergraduate research students to advance the understanding of this neglected tropical disease.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $130.0k | 9/8/25 |