Surveillance of drug-resistant bacteria in resource-limited settings: a focus on cost-effective long-read sequencing of eyedrop-associated p. Aeruginosa and locally sourced metagenomic samples
Active Project Grant Awarded Last action
- Award ID
- R16AI184350
- Recipient
-
California State University Fresno UEI GBATCBNV1SH8
- Awarding agency
-
National Institute of Allergy and Infectious Diseases
National Institutes of Health, Department of Health and Human Services
- Obligated
- $525,000
Award facts
- Assistance listing
- 93.855 Allergy and Infectious Diseases Research
- Completion date 54% complete
- Place of performance
- Fresno, CA 93740, USA
Award details come from USAspending.gov.
Description
- Abstract
- Surveillance of drug-resistant bacteria in resource-limited settings: a focus on cost- effective long-read sequencing of eyedrop-associated p. Aeruginosa and locally sourced metagenomic samples antimicrobial resistance (AMR) poses a growing threat to global public health, rendering antibiotics increasingly ineffective against drug-resistant bacteria. Recent episodes involving the contamination of preservative-free eyedrops with extensively drug-resistant (XDR) pseudomonas aeruginosa have resulted in hundreds of infection cases and three fatalities. This outbreak underscores that superbug occurrences are no longer confined to healthcare-associated settings, and we need a community-wide surveillance system that monitors local infection outbreaks efficiently in terms of time, accuracy, and cost. Such a system is essential to mitigate the adverse consequences of superbugs, encompassing a broad spectrum of sample types including medicinal and agricultural products. To achieve this long-term goal, this project first aims to test a decentralized AMR surveillance system in resource-limited settings by assessing the detection of drug- resistant bacteria and antimicrobial bacteriophages with cost-efficient long-read sequencing. We will use flongle platforms that enable the sequencing of smaller assays (
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $175,000 | |
| Amendment | $0 | |
| Amendment | $175,000 | |
| Original award | $175,000 |
Quick answers
Who received award R16AI184350?
R16AI184350 was awarded to California State University Fresno by National Institute of Allergy and Infectious Diseases (National Institutes of Health) on September 1, 2024.
How much is award R16AI184350 worth?
$525,000 has been obligated on R16AI184350.
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