Project Grant R16AG104203
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $435,875 to Vanderbilt University on May 15, 2026, under the Aging Research program (CFDA 93.866) to define characteristics of a resilient organelle interactome during aging. The research applies advanced 3D electron microscopy and artificial intelligence-based image analysis to map organelle interactions in Caenorhabditis elegans model organisms across the aging process. The work compares age-dependent...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $533,500 to the Buck Institute for Research on Aging on July 15, 2026, under the Aging Research program (CFDA 93.866). The award funds examination of the role of autonomic innervation in muscle stem cell aging. The research investigates the functional link between autonomic nervous system neurons and muscle stem cells using Drosophila melanogaster as a model organism. The project will refine...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded The Johns Hopkins University $427,625 for Project Grant R21AG102518 on September 1, 2026, under the Aging Research program (CFDA 93.866). The recipient will develop a human three-dimensional neuromuscular microphysiological system to model skeletal muscle aging ex vivo. The platform integrates primary human muscle stem cells from young (20–30 years) and aged (60–75 years) donors, induced pluripotent...
- The National Institute on Aging awarded New York University $708,137 on February 1, 2026, under the Aging Research program (CFDA 93.866) to develop and validate technologies for probing the biophysical properties of aging cells. The funded work centers on developing genetically encoded multimeric particles (GEMs) as high-throughput microrheology probes to measure the physical properties of cell interiors—particularly within organelles including the nucleus, cytoplasm, endoplasmic reticulum,...
- The National Institute on Aging awarded Drexel University $420,554 under Aging Research (CFDA 93.866) on September 1, 2026, to establish an integrated system for studying senescence and aging in the central nervous system. The award funds two research aims: characterization of the molecular and functional consequences of senescence in astrocyte and neuronal cultures, and evaluation of senescence impact in a multicellular context using hiPSC-derived vascularized cortical organoids. Single-cell...
- The National Institute on Aging awarded $648,930 to the Regents of the University of California, doing business as University of California, Berkeley, on August 15, 2026, under the Aging Research program (CFDA 93.866) to develop human stem cell-based microphysiological systems for aging research. The recipient will create a novel human aging-on-a-chip platform integrating fat and liver tissues derived from human induced pluripotent stem cells (hiPSCs) and microfluidics using serum from young...
- The National Institute on Aging awarded New York University $705,405 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate how changes in nuclear physical properties during cellular senescence drive transcriptional and splicing dysregulation characteristic of aging. The funded research measures nuclear biophysical properties across multiple length scales using a toolkit including genetically encoded multimeric nanoparticles (nucGEMS, 40–50 nanometers), newly...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $298,419 to the Regents of the University of Michigan on February 1, 2026, under the Aging Research program (CFDA 93.866, Assistance Listing Project Grant R01AG097771). The recipient will develop advanced statistical and computational methods for analyzing immune cell data to enhance understanding of the immune system's role in aging and age-related diseases. The project addresses analytical...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded The Trustees of Columbia University in the City of New York $149,190 on August 6, 2026, under the Aging Research program (CFDA 93.866) to investigate the molecular mechanisms by which NBR2, a long non-coding RNA, contributes to ovarian aging. The research addresses female-specific health conditions through genome-wide association studies and functional genomic studies in human ovarian cell models. The...
- The National Institute on Aging awarded Albany Medical College $246,000 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate inter-organelle dynamics during aging in eukaryotic cells. The work will characterize spatial contexts of inter-organelle communication using C. elegans as a model system to identify organellar signatures that develop during aging and proteostasis decline, establishing a platform to understand how aging impacts organelle interactions and...
The National Institute on Aging, part of the Department of Health and Human Services, awarded Old Dominion University $160,000 on September 1, 2026, to develop and test a three-dimensional bioprinted mammary model system for investigating age-related cellular dysfunction and regenerative microenvironment mechanisms under the Aging Research program (CFDA 93.866). The project addresses molecular mechanisms underlying cellular and tissue rejuvenation through a regenerative microenvironment model. The research builds on preliminary evidence that interactions with induced pluripotent stem cells can reduce tumor formation rates in breast cancer cells, and that extracellular vesicles isolated from pluripotent cells can promote healing, block senescence, and reduce molecular markers of aging. The work will develop a bioprinted mammary model system that overcomes current limitations of the gold-standard cleared mammary gland mouse model by providing a controllable platform to study how cells and tissues can be redirected or rescued from dysfunctional states through exposure to regenerative environments. Old Dominion University Research Foundation serves as the fiscal and administrative agent for the award. Performance occurs in Norfolk, Virginia. The award period runs from September 1, 2026, through May 31, 2030. The Aging Research program supports biomedical, social, and behavioral research directed toward understanding the aging process and associated diseases affecting older populations.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $160.0k | 8/31/26 |