Project Grant R15MH144559
- The National Institute of Mental Health awarded Yale University $711,168 under Mental Health Research Grants (CFDA 93.242) on September 1, 2026, to identify circuit mechanisms by which insular cortex immune-responsive neurons alter behavior during peripheral inflammation. The project uses mouse models of type 2 and type 3 inflammation combined with single-cell transcriptomics, electrophysiology, and chemogenetics to determine whether insular cortex immune-responsive neurons are heterogeneous and...
- The National Institute of Mental Health awarded the University of Pittsburgh $1,004,971 through the Mental Health Research Grants program (CFDA 93.242) on April 8, 2026, to develop a platform for measuring and analyzing brain activity, cognitive states, behavior, and physiology during multiday neural recordings in individuals undergoing surgical treatment for epilepsy. The project will integrate wearable technology and artificial intelligence for behavioral and physiological monitoring alongside...
- The National Institute of Mental Health awarded The Trustees of Columbia University in the City of New York $244,428 on August 20, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct research on cholinergic modulation of thalamocortical projections to prefrontal cortex in cognitive flexibility. The research will determine whether acute adult cholinergic modulation in the prefrontal cortex modulates attentional set-shifting performance and whether enhancing...
- The National Institute of Mental Health awarded the University of Illinois $440,908 on July 27, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support a project investigating the roles of the prefrontal cortex and ventral hippocampus during adolescence in the maturation of social and cognitive behaviors. The research examines how changes in GABAergic inhibitory transmission in these limbic structures contribute to the refinement of higher cognitive functions and social...
- The National Institute of Mental Health awarded the University of Wyoming $397,375 on June 10, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the role of medial prefrontal cortex long-range recurrent neural networks in behavioral initiation and inhibition. The project, R21MH141703, will employ four translational behavioral paradigms (head-fixed persistent licking and shock-escape tasks; freely moving Fed3-based reversal learning and stop-signal tasks) combined...
- The National Institute of Mental Health awarded the University of Miami $731,258 on March 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to map neural dynamics linked to major depressive disorder and generalized anxiety disorder using high-stakes real-world events. The recipient will conduct fMRI neuroimaging across five sessions with 144 undergraduate participants—72 diagnosed with GAD or MDD and 72 controls—leveraging naturally occurring emotional events during...
- The National Institute of Mental Health awarded Drexel University $409,824 on August 12, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate converging innervation of somatostatin neurons in the lateral septum by the prefrontal cortex and hippocampus. The research examines how somatostatin neurons in dorsal and ventral poles of the lateral septum receive distinct inputs from the infralimbic prefrontal cortex and hippocampal CA1 regions, with the hypothesis that...
- The National Institute of Mental Health awarded The Leland Stanford Junior University $426,991 under the Mental Health Research Grants program (CFDA 93.242) on August 3, 2026, to support research decoding medial prefrontal cortex (MPFC) plasticity across developmental life stages. The recipient is investigating critical periods of synaptic plasticity in the MPFC using high-throughput assays measuring long-term potentiation in mouse brain slices via multielectrode recording arrays. Aim 1 maps...
- The National Institute of Mental Health awarded University of California, Los Angeles $764,785 under the Mental Health Research Grants program (CFDA 93.242) on July 16, 2026, to investigate context-dependent disease mechanisms in neurodevelopmental disorders, specifically the 16p11.2 chromosomal deletion (16PDEL) implicated in autism, intellectual disability, and ADHD. The project will use a proprietary in vitro human stem cell platform called the Cell Village to conduct high-throughput...
- The National Institute of Mental Health awarded Northeastern University $157,500 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to explore the role of microglia in developmental effects of early life adversity on prefrontal cortex glutamate receptor development. The research investigates how microglia, resident immune cells of the brain, drive changes in NMDA receptor expression in adolescents exposed to early life adversity such as maternal separation. Prior...
The National Institute of Mental Health awarded Lafayette College $490,855 on August 15, 2026, under the Mental Health Research Grants program (CFDA 93.242) to examine the role of insula sub-circuits in attention-guided behavior. The research characterizes how two projection-specific insula neuron populations—those projecting to the locus coeruleus and those projecting to the prelimbic cortex—contribute to attentional processing. The work uses molecular, cellular, and circuit-level analysis combined with cutting-edge neuronal activity measurement techniques in a translational, touchscreen-based rodent continuous performance test analogue to mechanistically link insula function to attention-guided behavior. The project addresses attention deficits common across attention-deficit hyperactivity disorder, major depressive disorder, schizophrenia, and Alzheimer's disease, conditions in which the insula shows abnormal structure and function. Performance takes place in Pennsylvania. The period of performance runs through July 14, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $490.9k | 8/14/26 |