Project Grant R15HL181624
- Federal Project Grant Award Summary The University of Michigan received a $1,494,562 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 20, 2025, with completion targeted for June 30, 2030. The award supports the development of an innovative in situ micro-rheology technique utilizing ultrasound-responsive nanodroplets to non-invasively characterize aging thrombi in real-time. The core...
- Federal Grant Award Summary Michigan Technological University received a $410,956 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 1, 2025, through August 31, 2028. The award supports research titled "Stratifying Thrombosis Risk in Kawasaki Disease Using Hemodynamic Analysis Beyond the Z-Score," which addresses the clinical challenge of identifying thrombotic risk in patients...
- Federal Project Grant Award Summary Massachusetts Institute of Technology received a $397,034 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 1, 2025, with completion scheduled for July 31, 2027. The grant supports development of a transcatheter manufacturing toolkit for creating patient-specific, minimally-invasive left atrial appendage occlusion (LAAO) devices to prevent stroke in...
- Federal Grant Award Summary Michigan Technological University received a $589,998 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 1, 2025, through August 31, 2028. The award supports research investigating cardiac sensory and sympathetic nerve dysregulation in hypertrophic cardiomyopathy (HCM), a genetic heart disease affecting approximately 1 in 500 individuals and representing the...
- Federal Project Grant Award Summary Wayne State University received a $756,148 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded July 1, 2026, with completion targeted for March 31, 2030. The award supports development of next-generation enabling technologies for ultrafast functional pulmonary magnetic resonance imaging (MRI) using hyperpolarized xenon-129 gas. The project addresses a critical...
- Federal Grant Award Summary Lawrence Technological University received a $422,247 Project Grant from the National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems (CFDA 47.041) awarded on September 15, 2025, with completion targeted for December 31, 2026. This collaborative research initiative, conducted in partnership with the University of Texas at El Paso and Baylor College of Medicine, investigates the interaction between nanometer-scale...
- Federal Project Grant Award Summary Oakland University received a $249,000 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded on August 11, 2025, with a completion date of July 31, 2028. The research focuses on pre-mRNA processing and function of alternatively spliced isoforms of Tissue Factor Pathway Inhibitor (TFPI), a critical anticoagulant protein that maintains hemostatic balance by modulating...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Massachusetts a $425,971 Project Grant (CFDA 93.837 – Cardiovascular Diseases Research) effective July 6, 2026, through June 30, 2028, to develop a biomaterials-integrated microphysiological bone marrow chip model. The project aims to create a physiologically relevant preclinical system that recapitulates the structural and functional interdependence of bone and bone marrow...
- Federal Project Grant Summary The University of Michigan, through its Office of Research and Sponsored Projects, received a $191,629 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective May 15, 2026, with completion targeted for April 30, 2031. The research addresses venous thromboembolism (VTE) risk in pregnant and postpartum patients with sickle cell disease (SCD), a medically vulnerable...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $429,000 Project Grant to the Regents of the University of Michigan on August 15, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop a rapid, non-contrast, low-field magnetic resonance imaging (MRI) pipeline for detecting pulmonary embolism (PE). The project, which extends through July 31, 2027, focuses on creating an efficient 3D, contrast-free MRI protocol utilizing...
Lawrence Technological University received a $444,589 Project Grant award (issued July 10, 2026; completion targeted June 30, 2029) from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The grant supports the development of multiscale computational modeling to assess shear-induced bleeding risk in blood-contacting medical devices (BCMDs). The primary deliverable is a physics-based computational model that reveals correlations between BCMD design characteristics and variations in von Willebrand factor (VWF) degradation and platelet receptor dysfunction—key mechanisms underlying device-induced bleeding complications in heart support and replacement devices. The research encompasses three specific aims: (1) developing multiscale models that elucidate VWF degradation and platelet receptor shedding mechanisms; (2) identifying key geometric parameters of BCMDs that drive device-induced variations in VWF and platelet responses; and (3) leveraging the developed models to optimize a new BCMD design with enhanced hemocompatibility and reduced bleeding risk. Upon completion, the project will deliver a comprehensive, clinically relevant understanding of how device design influences hemostatic dysfunction, ultimately supporting safer medical device design and improved patient outcomes.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $444.6k | 7/7/26 |