Project Grant R15HL181599
Award Date 8/15/26
Completion Date 4/30/29
Dollars Obligated $536K
Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
West Des Moines, IA 50266, USA
Similar Awards
- The National Heart, Lung, and Blood Institute awarded Brigham & Women's Hospital Inc. $133,220 on August 17, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct an ancillary study characterizing the burden and nature of 11-beta-hydroxysteroid dehydrogenase type 2 (11βHSD2) insufficiency in people with diabetes at risk for chronic kidney disease. The study examines how cortisol-mediated mineralocorticoid receptor (MR) activation contributes to chronic kidney...
- The National Heart, Lung, and Blood Institute awarded The University of Iowa $743,341 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to elucidate the role of insulin receptor substrate 2 (IRS2) in cardiac calcium homeostasis and arrhythmogenesis. The research addresses sudden cardiac death from ventricular arrhythmias following myocardial infarction, driven by chronic sympathetic overactivation that disrupts cardiomyocyte calcium homeostasis and triggers...
- The National Heart, Lung, and Blood Institute awarded The University of Iowa $599,466 on August 19, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to fund research examining the cellular and molecular mechanisms driving submucosal gland hypertrophy in chronic lung diseases including asthma, COPD, and cystic fibrosis. The funded research will identify fundamental pathways responsible for pathological gland enlargement by defining key cell-cell interactions and signaling...
- The National Heart, Lung, and Blood Institute awarded The University of Iowa $143,080 on December 6, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to support research into the cardiotoxic effects of monoamine oxidase (MAO) metabolism of catecholamines in obesity. The award funds a dissertation project investigating how three reactive metabolites produced by MAO—hydrogen peroxide, ammonia, and catecholaldehydes—individually contribute to mitochondrial dysfunction and...
- The National Heart Lung and Blood Institute awarded New York University School of Medicine $795,421 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate sex-specific responses to obstructive sleep apnea therapies. The research examines how oxidative stress mediates cardiovascular harm from obstructive sleep apnea, with particular focus on sex differences in treatment response. The study tests N-acetylcysteine, an antioxidant precursor that...
- The National Heart, Lung, and Blood Institute awarded the University of Oklahoma Health Sciences Center $638,245 on August 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate hypothalamic melanocortin 4 receptor (MC4R) signaling pathways in sympathetic regulation of blood pressure, with particular focus on obesity-induced hypertension mechanisms. The research examines how MC4R signaling in hypothalamic neurons regulates sympathetic outflow and blood...
- The National Heart, Lung, and Blood Institute awarded the University of California Irvine a project grant of $214,071 on September 30, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837). The award funds research investigating the cardiac response to obstructive sleep apnea through an in-vitro heart-on-a-chip platform combined with intermittent hypoxia protocols. The research will develop and validate physiologically relevant intermittent hypoxia protocols using endothelial...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Sanford Research $350,000 on August 5, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate molecular regulators of collecting duct remodeling and their role in water and ion homeostasis. The project examines cellular and molecular mechanisms governing the composition and function of the kidney's collecting duct, specifically the balance between principal cells and...
- The National Heart, Lung, and Blood Institute awarded the University of Utah $248,999 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) for basic research into WNK1-dependent macropinocytosis and emergency myelopoiesis. The project investigates how the chloride-sensing kinase WNK1 regulates myeloid progenitor cell fate, particularly the shift from monocyte/macrophage lineage commitment toward emergency granulopoiesis during systemic infection. Research...
- The National Heart, Lung, and Blood Institute awarded The University of Iowa $622,619 on August 15, 2026, to conduct research targeting hypothalamic astrocytes in obesity-associated hypertension under the Cardiovascular Diseases Research program (CFDA 93.837, Project Grant R01HL187653). The project investigates how chronic overnutrition alters brain circuits through elevated adipose hormone leptin, causing increased sympathetic outflow and blood pressure elevation. The research focuses on...