Project Grant R15HL179371
- The National Heart, Lung, and Blood Institute awarded the University of North Carolina at Chapel Hill $166,248 on September 26, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct research triangulating causal effects of sleep, inflammation, and cardiometabolic disease. The research will identify oxylipin biomarkers associated with sleep problems—including insomnia, sleep apnea, and short sleep duration—and their relationship to cardiometabolic disease. The study...
- The National Institute of Mental Health awarded The Rand Corporation $792,687 on August 17, 2026, under the Mental Health Research Grants program (CFDA 93.242) to adapt and pilot test a transdiagnostic sleep and circadian intervention for adolescents aged 14–17 exposed to early life adversity and experiencing sleep disturbances. The project, titled "Improving Sleep and Emotional Well-Being in Adolescents with Early Life Adversity: A Transdiagnostic Sleep and Circadian Intervention,"...
- The National Heart, Lung, and Blood Institute awarded Emory University $100,228 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct longitudinal research examining associations between sleep health, protective factors against psychosocial adversity, and stress-related biomarkers including allostatic load and epigenetic age acceleration. The project analyzes multidimensional sleep health—encompassing regularity, satisfaction, alertness, timing,...
- The National Heart Lung and Blood Institute awarded Brigham & Women's Hospital $3.243748 million on September 23, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the role of ambient lighting in circadian misalignment within a chronic variable sleep deficiency paradigm and its impacts on sleep, cognition, and central oxidative stress. The research examines how irregular sleep schedules—common among U.S. adults accommodating social and work...
- The National Heart, Lung, and Blood Institute awarded Rush University Medical Center $783,899 on July 5, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to examine the impact of early elementary school start times on sleep health, learning, attention, and obesity in young children through second grade. The study enrolls 200 kindergartners—50 night owls and 50 morning larks attending early-start schools (by 8:00 a.m.), and 50 night owls and 50 morning larks attending...
- The National Heart Lung and Blood Institute awarded Emory University $248,705 on February 2, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate relationships between naturalistic light exposure and sleep regularity. The project examines how dimensions of light exposure impact sleep regularity and identifies biological markers of sleep regularity, with investigation of moderation by factors such as age and sex. The research develops and validates findings...
- The National Heart, Lung, and Blood Institute awarded the University of Arizona $739,230 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop and test "DUERME MEJOR," a community health worker–led sleep health intervention adapted for Mexican Americans at the US-Mexico border. The project develops a multimodal intervention combining cognitive behavioral therapy for insomnia and systematic sleep time extension, addressing documented sleep...
- The National Heart, Lung, and Blood Institute awarded Mayo Clinic $242,100 on August 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate treatment-resistant insomnia, with work completed by July 31, 2028. Mayo Clinic will define and quantify the prevalence of treatment-resistant insomnia in a real-world clinical sample using electronic health record data from the Mayo Clinic Biobank and Mayo Clinic Tapestry Project, supplemented by chart review validation....
- The National Institutes of Health National Heart Lung and Blood Institute awarded Mayo Clinic Arizona $243,678 on December 21, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct a multisite longitudinal study characterizing sleep health, sleep disorders, and cognitive functioning in heart transplant recipients. The study will enroll 30 adult heart transplant recipients who are at least six months post-transplant and obtain repeated measures at nine and twelve...
- The National Institute of Mental Health awarded Boston Children's Hospital $153,560 on January 7, 2027, under the Mental Health Research Grants program (CFDA 93.242) to conduct a postdoctoral fellowship examining the relationship between sleep physiology, myelin content, and depressive symptoms in young people ages 9–26 years. The research leverages data from two ongoing R01 studies to investigate two specific aims: understanding the relationship between sleep EEG signatures (spindles and slow...
The National Heart, Lung, and Blood Institute awarded the University of Redlands $474,780 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct a randomized crossover study examining oral and transdermal melatonin as treatment for insufficient sleep in youth at risk for mental health disorders. The research will characterize the absorption and metabolism of lotion-based melatonin over 48 hours using salivary sampling, comparing it to oral supplements and placebo controls. Study participants aged 14–21 years at risk for mental health problems will complete seven-day treatment arms, with investigators measuring sleep via wrist-worn activity trackers and diaries; autonomic nervous system balance through heart rate variability and salivary alpha-amylase; and mood and anxiety symptoms through daily questionnaires. Salivary melatonin samples will confirm adherence to the protocol. The study will examine correlations between changes in sleep and autonomic nervous system parameters and improvements in anxiety and depression symptoms to probe treatment mechanisms and assess whether sleep improvements or autonomic activity represent potential links to mental health benefits. Performance occurs in Redlands, California, with a period of performance from September 1, 2026, through August 31, 2029. The award is classified as a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $474.8k | 9/1/26 |