Project Grant R15GM166965
- The National Institute of General Medical Sciences awarded Oklahoma State University $373,960 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on genome evolution and design in small, single-stranded DNA phages (Microviridae). The award is structured as a Project Grant with a period of performance running through August 31, 2031. Work is performed in Oklahoma City, Oklahoma. The National Institute of General Medical Sciences...
- The National Institute of General Medical Sciences awarded Massachusetts Institute of Technology $127,567 on September 3, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate mechanisms of nuclease-based bacterial immunity systems. The research, carried out in Cambridge, Massachusetts, through August 31, 2028, combines genetic and molecular biology approaches with training in biochemistry, structural biology, and computational methods to dissect how...
- The National Institute of General Medical Sciences awarded the University of Virginia $425,145 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop integrated microscopy and image processing technologies for long-term three-dimensional fluorescence imaging of bacterial biofilm communities on and within living human epithelial tissues. The project will create imaging and tracking systems capable of measuring single-cell three-dimensional bacterial...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $400,790 to The Trustees of Davidson College to conduct research on old family nuclease function across diverse anti-phage defense systems in bacteria. The primary goal is to investigate the molecular mechanisms of both class 1 and class 2 old proteins, as well as the interactions between class 2 old proteins and their associated...
- The National Institute of General Medical Sciences awarded Georgia State University Research Foundation Inc. $434,729 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on bacteriophage gene essentiality and infection dynamics across environmental contexts. The award funds research to map phage gene function and track infection dynamics using complementary molecular approaches. The work will exploit DNA mismatch-repair deficient...
- The National Institute of General Medical Sciences awarded Health Research, Inc. Wadsworth Center $386,003 on August 1, 2026, to fund research on mechanisms of bacterial defense against conjugative plasmids and their phages under the Biomedical Research and Research Training program (CFDA 93.859). The research addresses antibiotic resistance by investigating how bacteria defend against conjugative plasmids—which spread resistance genes across bacterial populations—and plasmid-dependent phages...
- The National Institute of General Medical Sciences awarded Virginia Polytechnic Institute & State University $402,500 on July 1, 2026, for Project Grant R35GM165568 under the Biomedical Research and Research Training program (CFDA 93.859). The award funds investigation into mechanisms of virus-host conflict at the level of cell death. The research examines how viral and host factors, together with spatial context, determine whether infected cells survive or undergo regulated cell death—a...
- The National Institute of General Medical Sciences awarded the University of Virginia $441,474 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate how ion channels orchestrate endolysosomal system functions in myeloid phagocytes. The research pursues three complementary directions: characterizing how M7VS (specialized TRPM7-containing vesicles) drive phagosome maturation and endolysosomal homeostasis; dissecting the dual channel-kinase...
- The National Institute of General Medical Sciences, part of the Department of Health and Human Services National Institutes of Health, awarded the University of Virginia $706,860 on September 15, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the regulation of ceramide-1-phosphate metabolism in cell signaling networks and metabolic reprogramming. The research examines how ceramide-1-phosphate, a bioactive sphingolipid produced by ceramide kinase,...
- The National Institute of General Medical Sciences, part of the National Institutes of Health within the Department of Health and Human Services, awarded Southern Methodist University $380,626 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The award funds research into functional activation of P53 by reverse transcriptase processes, with emphasis on P53's role in suppressing retrotransposons—mobile genetic elements implicated in human disease. The...
The National Institute of General Medical Sciences awarded the College of William and Mary $571,875 on September 5, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct functional characterization of novel phage satellites in mycobacteria. The research will advance fundamental understanding of mycobacterium phage satellite biology—mobile genetic elements that parasitize helper phages to complete their life cycles. The college's laboratory discovered extracellular prophage-inducing particles (EPIPs), the first phage satellites identified in the mycobacterial genus, which consistently trigger excision and activation of the helper prophage HerbertWM from Mycobacterium aichiense. The project will quantify temporal gene expression dynamics of the host, helper phage, and satellite during infection through RNA sequencing and mass spectrometry; determine satellite gene functions through overexpression and targeted knockouts; and characterize host range and prevalence in natural environments. Work will be performed in Virginia and runs through August 31, 2029. This is a Project Grant, the assistance type NIGMS uses for investigator-initiated basic research spanning approximately nine months of review and award decision time.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $571.9k | 9/2/26 |