Project Grant R15GM166766
- The National Institute of General Medical Sciences awarded $422,688 to the Regents of the University of California at Riverside on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, Assistance Listing 93.859). The award funds basic research on cell signaling through the primary cilium, a microtubule-based organelle that functions as the cell's signaling hub. The research addresses how the primary cilium senses environmental signaling cues and transduces...
- The National Institute of General Medical Sciences awarded The University of Texas Southwestern Medical Center $556,694 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support structural and functional analysis of ciliary complexes, with work performed in Dallas, Texas through March 31, 2031. The award funds an integrated research program combining structural cell biology, disease-focused analysis, and technical innovation to advance...
- The National Institute of General Medical Sciences awarded The Administrators Of Tulane Educational Fund (Tulane University) $420,750 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the context-specific functions of the CDK8 kinase module of the Mediator complex. The research addresses how the CDK8-cyclin C complex regulates transcriptional responses to environmental and dietary cues, with specific focus on three questions: how...
- The National Institute of General Medical Sciences awarded The Ohio State University $441,570 on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to explore actin cytoskeleton organization and function in health and disease. The project runs through April 30, 2031, with performance at Columbus, Ohio. The research advances understanding of how actin-binding proteins called plastins organize actin filaments into higher-order assemblies—bundles and networks—and...
- The National Institute of General Medical Sciences awarded the University of Wisconsin – Madison $249,000 on July 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate TULP3 protein function in primary cilia signaling and ciliogenesis. The research addresses defects in primary cilia—cellular signaling hubs that sense extracellular signals including odorants, metabolites, light, and neurotransmitters—which are linked to developmental disorders,...
- The National Institute of General Medical Sciences awarded The Salk Institute for Biological Studies $515,625 on June 12, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate fundamental mechanisms of cytoskeletal dynamics and transport, with focus on how connector proteins link molecular motors to cellular cargo and facilitate transport along microtubule tracks. The research examines two primary areas: the role of spectraplakin proteins, which link...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $686,308 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate how microtubule- and actomyosin-based cytoskeletal networks are spatially regulated during cell division and development. The research integrates experiments in C. elegans embryos and cultured human cells, focusing on centrosomes and their role as microtubule-organizing centers. Work...
- The National Institute of General Medical Sciences awarded Jackson Laboratory $506,000 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the interplay between quaking (QKI) isoforms and N7-methylguanosine (M7G) RNA modifications in controlling post-transcriptional gene regulation during cellular differentiation. The project will develop novel methods for base-resolution M7G detection using direct RNA long-read sequencing and orthogonal...
- The National Heart, Lung, and Blood Institute awarded the University of Toledo $561,300 under the Cardiovascular Diseases Research program (CFDA 93.837) on September 1, 2026. The award funds research into the ERK1/2-C-FOS/EGR1/2 pathway in GFI1- and C/EBP-mediated granulopoiesis, specifically investigating how transcription factors GFI1 and C/EBPA promote neutrophil development. The research will test hypotheses that these factors instruct neutrophil fate in part through negatively regulating...
- The National Institute of General Medical Sciences awarded the University of Rochester $578,733 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to elucidate the biological roles of tRNA modification enzymes. The award funds research combining biochemistry, molecular biology, and genetics to resolve knowledge gaps about how tRNA modifications impact tRNA structure and function, the roles of vertebrate-specific tRNA modification enzymes, and how these...
The National Institute of General Medical Sciences awarded the University of Toledo $573,750 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to characterize centrosomal JAK2 localization in ciliated cells and define how it regulates ciliogenesis and downstream cellular functions. The research investigates JAK2, a non-receptor protein tyrosine kinase, as a novel component of centrosome-associated complexes and its role in controlling cilia formation, cilia-based signaling, cell-cycle progression, and cell migration in normal and disease states. The work addresses a knowledge gap in spatial regulation of JAK2 at the centrosome to establish fundamental mechanisms by which centrosomal JAK2 contributes to ciliopathies and cancer. Work is performed in Ottawa Hills, Ohio, with a period of performance extending from September 1, 2026, through August 31, 2029. The research is structured around two specific aims: determining whether centrosomal JAK2 regulates ciliogenesis and cilia-dependent cell functions, and characterizing centrosomal JAK2's role in the centrosome-associated complex through mechanisms informed by preliminary experimental data.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $573.8k | 8/5/26 |