Project Grant R15GM164975
- The National Institute of General Medical Sciences awarded the University of North Carolina at Chapel Hill $528,497 under the Project Grant R35GM163509 on August 1, 2026, to support basic research into eukaryotic centromere structure and function under the Biomedical Research and Research Training program (CFDA 93.859). The research develops computational tools and integrates experimental imaging data to interrogate the structure and dynamics of pericentromeric DNA—chromatin spanning hundreds of...
- The National Institute of General Medical Sciences awarded the University of New Orleans $372,500 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, Assistance Type: Project Grant) to investigate the role of lipid metabolism in germline-soma interactions and stress responses using Caenorhabditis elegans as a model organism. The research examines how increased germline activity—specifically in mated hermaphrodite worms compared to self-fertilized...
- The National Institute of General Medical Sciences awarded the University of North Carolina at Chapel Hill $533,425 on July 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to define new roles of the E3 ligase RNF25 in DNA replication and stress signaling. The research addresses DNA replication stress—a slowing of DNA synthesis that threatens genome integrity—by investigating how cells mount DNA damage response signaling to coordinate resolution of stalled...
- The National Institute of General Medical Sciences awarded the University of North Carolina at Chapel Hill $470,963 on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct enhanced sampling of intracellular protein interactions with G-protein-coupled receptors (GPCRs). The project develops computational methods to characterize the lifetime and dissociation kinetics of GPCR-G protein and GPCR-arrestin complexes using molecular dynamics simulation...
- The National Institute of General Medical Sciences awarded the University of North Carolina at Chapel Hill $413,946 under the Biomedical Research and Research Training program (CFDA 93.859) on April 5, 2026, to support basic research elucidating the molecular determinants of functional specificity in intrinsically disordered proteins (IDPs). The project investigates how IDPs achieve functional specificity through multivalent interactions—the linkage of multiple binding motifs within a single...
- The National Science Foundation Division of Molecular and Cellular Biosciences awarded the University of North Carolina at Chapel Hill $993,620 on August 1, 2026, under the Biological Sciences program (CFDA 47.074) to investigate molecular and cellular mechanisms that enable tardigrades to survive extreme environmental stresses. The research seeks to identify protective molecules and determine how protective systems operate within living tardigrades exposed to desiccation and related stresses...
- The National Institute of General Medical Sciences awarded the University of North Carolina at Chapel Hill $432,135 on May 15, 2026, through the Biomedical Research and Research Training program (CFDA 93.859) to investigate the molecular mechanisms of myosin-X (MYO10) and filopodial function. The research addresses how MYO10 promotes filopodia formation and identifies its molecular cargo; characterizes headless MYO10, a motor-domain-lacking variant expressed in brain and stem cells; purifies...
- The National Institute of General Medical Sciences awarded the University of North Carolina at Greensboro $1.329 million on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop cost-effective workflows for unsaturated lipidomics analysis. The recipient will extend a novel ion chemistry called OZNOXESI beyond phospholipids to all lipid classes, particularly glycerolipids and sphingolipids, enabling determination of carbon-carbon double bond (C=C)...
- The National Institute of General Medical Sciences at the Department of Health and Human Services awarded Duke University $118,494 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the molecular basis of basement membrane elasticity and cyclic fatigue resistance. The research uses C. elegans ovulation as an experimental system to study how basement membranes in tissues such as the lung and vasculature withstand repeated cycles of...
- The National Institute of General Medical Sciences awarded East Carolina University $168,918 on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate mechanisms that establish a functional stem cell niche during organogenesis. The recipient will conduct laboratory work using an in vivo live imaging method in the developing Drosophila testis to explore how niche cells are specified, how cytoskeletal regulators enable niche morphogenesis, and what...
The National Institute of General Medical Sciences awarded the University of North Carolina at Wilmington $546,500 on August 8, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate non-canonical roles of phosphagen kinases in cellular and organismal stress responses. The recipient will use Caenorhabditis elegans as a model system to identify which of three different versions of phosphagen kinases support tolerance to diverse stresses, test whether these kinases protect cells through antioxidant-like mechanisms while preserving energy machinery function, and determine tissue-specific effects through genetic manipulation. The work will also employ genetic sequencing technologies to characterize how phosphagen kinase function alters the activity of other enzymes and genes that support stress response. The research aims to illuminate mechanisms that could inform novel targets for aging and disease intervention. Work is performed in Wilmington, North Carolina, with a period of performance extending from August 8, 2026 to August 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $546.5k | 8/6/26 |