Project Grant R15GM164964
- Federal Grant Award Summary Oakland University received a $562,320 Project Grant award effective September 1, 2025, through August 31, 2028, from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859). This award funds fundamental biomedical research investigating the role of pseudouridine synthases in autophagy—a critical cellular degradation and recycling pathway essential for cell survival under stress conditions. The...
- Federal Project Grant Award Summary Oakland University received a $565.8K Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded March 1, 2026, with a completion date of February 28, 2029. The award supports fundamental research investigating how cells recover from chronic stress, specifically examining the transcriptional regulation mechanisms that enable cellular recovery following...
- Federal Grant Award Summary Oakland University received a $562,500 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to conduct fundamental research on RNA Binding Motif Protein 48 (RBM48) and its role in U12 intron splicing, cellular differentiation, and development. The project, which commenced on September 11, 2025, and extends through August 31, 2028, will employ cellular, genetic,...
- Federal Grant Award Summary The University of Michigan received a $400,881 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded February 26, 2026, with performance extending through December 31, 2030. This research initiative aims to uncover the principles of morphogenetic modularity—how tissues acquire their intricate shapes and functions during development—by studying early brain and...
- Federal Project Grant Summary Augusta University Research Institute, Inc. received a $555,000 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, through August 31, 2028. The award supports fundamental research investigating the endocytic mechanisms required for mechanosensitive Notch receptor activation in vivo. The research focuses on understanding how ligand...
- Federal Project Grant Award Summary The University of Rochester received a $399,198 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, through June 30, 2030. This five-year award supports fundamental research investigating the dynamics of cell-matrix mechanical communication during morphogenesis—specifically, how mechanical signals from the extracellular matrix (ECM)...
- Federal Project Grant Award Summary The University of Michigan received a $523,888 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded on May 7, 2025, with a completion date of January 31, 2027. This grant funds fundamental biomedical research focused on elucidating the mechanisms by which cells select and modify individual microtubules through post-translational modifications (PTMs) of...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded Columbia University's Health Sciences Division a $2.25 million Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to conduct molecular genetic dissection of tube morphogenesis in the Drosophila tracheal system. The award, obligated on September 16, 2025, with a completion date of September 15, 2029, supports fundamental research investigating how seamless...
- Federal Grant Award Summary Oakland University received a $249,000 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 11, 2025, through July 31, 2028. The research project focuses on investigating pre-messenger RNA (pre-mRNA) processing and the function of alternatively spliced isoforms of tissue factor pathway inhibitor (TFPI), a critical anticoagulant protein that maintains hemostatic...
- Federal Grant Award Summary Cornell University's Office of Sponsored Programs received a $428,202 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 1, 2025, through May 31, 2030. The award supports fundamental research into the mechanisms of robustness in organogenesis, specifically investigating how developing organs achieve consistent size and shape despite cellular...
Grant Award Summary Oakland University received a $573,750 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to investigate how apical extracellular matrices (AECMs) regulate tube morphogenesis during development. The award, effective June 1, 2026, through May 31, 2029, supports fundamental basic research utilizing Drosophila tracheal development as a model system. The research will employ CRISPR-generated double mutants of osiris proteins (OSI18 and OSI20) to selectively disrupt taenidial folds—spiral, ridge-like AECM structures—and examine their regulatory role in tube formation, apical actin organization, and mechanotransduction pathway activation. This investigator-initiated research addresses a critical gap in understanding stable AECMs, which are essential structures lining the inner surfaces of mammalian organs including lungs, kidneys, and blood vessels. By characterizing how taenidial folds function beyond their traditional structural support role, the research establishes foundational knowledge applicable to human diseases caused by disrupted AECMs, such as pulmonary airway malformations and polycystic kidney disease. The project will be conducted at Oakland University's facility in Rochester, Michigan, and represents NIGMS's commitment to supporting meritorious basic biomedical research that advances understanding of fundamental biological processes.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $573.8k | 4/13/26 |