Project Grant R15GM160943
- This Project Grant award of $259,966, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop new synthetic strategies to functionalize pyridine and diazine heterocycles. The goal is to introduce novel methods for directly and selectively installing a range of substituents on these heterocycles, which are widely used in medicinal chemistry. The project will explore three approaches: 1)...
- This federal Project Grant award of $386,617 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) aims to develop safer and more efficient chemical methods for the synthesis of complex, fluorinated, and highly functional pharmaceutical compounds. The key research areas encompass: (1) electromicellar catalysis for the formation of fluorinated heterocycles, allenes, and reactive intermediates; (2) enantioselective...
- This federal Project Grant award of $524,400.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The funding supports research at the Scripps Research Institute in La Jolla, CA to develop novel chemical transformations and catalysts that enable the efficient synthesis of structurally complex small molecules for drug discovery. The research aims to address challenges in organic synthesis by...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $552,403 Project Grant to The Trustees of Columbia University in the City of New York. The grant, effective September 1, 2025 through August 31, 2030, will support research to develop innovative methods for the selective synthesis of functionalized amines and heterocycles from common feedstock chemicals. The research aims to address unmet needs in...
- This $412,632 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to advance the biocatalytic synthesis of complex medicinal small molecules. The award, with a performance period from August 1, 2025 to July 31, 2030, will fund the development of computer-aided synthesis planning (CASP) tools to generalize known enzymatic reactions and predict routes for producing...
- This federal Project Grant award of $620,000 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports a research project at Boston College focused on "Catalytic Radical Processes for Stereoselective Chemical Synthesis." The research aims to establish metalloradical catalysis as a framework for controlling the reactivity and stereoselectivity of homolytic radical reactions in organic synthesis. The...
- This federal Project Grant award of $146,816.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports research to develop general strategies for the biocatalytic synthesis of N-N and C-N heterobiaryl atropisomers, a class of medicinally relevant chiral compounds that are difficult to obtain through other methods. The research outlined will employ bioinformatic techniques to...
- The National Institute of General Medical Sciences (NIGMS) awarded a $422,569 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Vanderbilt University, effective May 1, 2025 through April 30, 2030. The funding supports the development of new reactions and reagents to generate enantioenriched organic compounds that can serve as precursors for medicinal agents and biologically active natural products. The proposed methods target the synthesis of secondary...
- This federal Project Grant award for $874,000.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research on enantioselective and site-selective C-H activation reactions. The key objectives are to develop next-generation ligands capable of enantio- and site-selective C(SP3)-H activation of aliphatic carboxylic acid substrates, as well as to achieve enantio- and site-selective ring...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $385,298 project grant to The Research Foundation for The State University of New York (Stony Brook University) for the period of February 1, 2025 to December 31, 2029. The project aims to develop a new biomimetic organic synthesis approach that leverages rationally designed pyridoxal-5'-phosphate (PLP)-mimicking catalysts to enable open-shell radical...
This federal Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to develop an efficient synthetic tool for the enantioselective construction of fused heterocyclic compounds with bridgehead quaternary carbons. The $548,701 award to Bryn Mawr College will be used to explore the use of chiral copper catalysts to facilitate the enantioselective desymmetrizing hydroamination reaction, which has applications in the synthesis of small molecule drugs containing heterocyclic rings and tetrahedral carbons. This research aims to address the challenge of constructing all-carbon quaternary carbons, which are common in bioactive molecules but lack a general synthetic method. The award period runs from Sep 1, 2025 to Aug 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $548.7k | 8/25/25 |