Project Grant R15GM159337
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The University of Southern Mississippi $149,041 under the Allergy and Infectious Diseases Research program (CFDA 93.855) for a two-year Project Grant commencing July 1, 2025 and concluding June 30, 2027. The award supports the development of novel tumor necrosis factor (TNF) secretion assays designed to distinguish between soluble TNF (sTNF) and membrane-bound TNF (mTNF) release mechanisms....
- The National Institute of General Medical Sciences awarded the University of Mississippi Medical Center $381,974 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, Project Grant T32GM163810) to establish and grow a Medical Scientist Training Program (MSTP) training physician scientists and clinician researchers. The award funds MD/PhD student training across multiple graduate disciplines including cellular and molecular biology, microbiology and...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The University of Southern Mississippi $750,000 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on September 20, 2025, with a completion date of August 31, 2029. This Project Grant supports investigator-initiated research aimed at elucidating the role of extracellular polyphosphate in Mycobacterium tuberculosis (MTB) antibiotic tolerance, with particular focus on how the...
- The National Institute of General Medical Sciences awarded the University of Tennessee $413,069 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct research on spatial regulation of plasma membrane signaling through super-resolution fluorescence imaging. The research focuses on how receptor signaling complexes are assembled and regulated by heterogeneous membrane structure in T cells, specifically examining T cell receptor activation and...
- The National Institute of General Medical Sciences awarded $429,072 to the University of Connecticut Health Center on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the molecular mechanism of necroptosis mediated by the mixed lineage kinase-like (MLKL) protein. The research addresses the structure-activity relationship of MLKL, the terminal executioner of necroptosis—a pro-inflammatory form of lytic cell death implicated in cancer,...
- The National Institute of General Medical Sciences awarded the University of South Florida $474,102 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct synthetic biology and genome engineering of polyketide natural products, develop bioactive metabolites from Antarctic marine invertebrates and deep-sea organisms, synthesize chemical analogs to modulate toxicity and enhance drug-like properties, and advance compound development initiatives...
- The National Institute of General Medical Sciences, part of the National Institutes of Health within the Department of Health and Human Services, awarded Southern Methodist University $380,626 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The award funds research into functional activation of P53 by reverse transcriptase processes, with emphasis on P53's role in suppressing retrotransposons—mobile genetic elements implicated in human disease. The...
- The National Institute of General Medical Sciences awarded the University of Massachusetts $2.35 million on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate non-specific electrostatic interactions of biological macromolecules in physiological and pathological processes. The project examines how highly charged polycationic and polyanionic biomacromolecules — including heparin, neutrophil extracellular traps, and other polymeric species —...
- The National Institute of General Medical Sciences awarded the University of Missouri System $418,822 on April 5, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to advance mechanistic understanding of membrane interfaces. The research addresses two primary areas: understanding the mechanism by which candidalysin, a peptide virulence factor secreted by Candida albicans, attacks host cell membranes by forming pores in lipid bilayers; and defining the mechanism of...
- The National Institute of General Medical Sciences awarded The Administrators Of Tulane Educational Fund (Tulane University) $420,750 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the context-specific functions of the CDK8 kinase module of the Mediator complex. The research addresses how the CDK8-cyclin C complex regulates transcriptional responses to environmental and dietary cues, with specific focus on three questions: how...
The National Institute of General Medical Sciences awarded The University of Southern Mississippi $562,443 on August 3, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the origin, secretion, and function of membrane-bound tumor necrosis factor (mTNF) bearing extracellular vesicles released from mast cells. The research dissects unconventional TNF release pathways in mast cells, focusing on how mTNF localizes to multivesicular body-like granules and associates with extracellular vesicles during secretion. The work challenges the conventional understanding that TNF is released only as a soluble proteolytic product, with significant implications for understanding inflammatory and immune disorders where mast cell-derived TNF plays a pathogenic role. The investigator's long-term goal is to identify mast cell exocytosis signaling pathways that could serve as therapeutic targets for mast cell diseases. Work is performed at Hattiesburg, Mississippi, with a period of performance from August 3, 2026, through July 31, 2029. The award is classified as a Project Grant, an assistance type typical of NIGMS's portfolio of investigator-initiated basic research supporting early-stage and at-risk investigators.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $562.4k | 8/3/26 |