Project Grant R15GM159331
- This federal Project Grant award of $524,400.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The funding supports research at the Scripps Research Institute in La Jolla, CA to develop novel chemical transformations and catalysts that enable the efficient synthesis of structurally complex small molecules for drug discovery. The research aims to address challenges in organic synthesis by...
- This federal Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), is funding research to develop novel metal complexes based on abundant first-row metalate species for use as catalysts in biomedical and chemical applications. The $147,025 award to the University of California, Merced will support research efforts in two key areas: 1) Investigating the structural and electronic...
- This federal Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of new reagents and methods for synthesizing oligophosphate constructs - phosphorylated biomolecules that play essential roles in human physiology and health. The $444,262 award, effective June 1, 2025 through March 31, 2030, will enable the Massachusetts Institute of Technology (MIT) to: Develop...
- This federal Project Grant award of $620,000 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports a research project at Boston College focused on "Catalytic Radical Processes for Stereoselective Chemical Synthesis." The research aims to establish metalloradical catalysis as a framework for controlling the reactivity and stereoselectivity of homolytic radical reactions in organic synthesis. The...
- This federal Project Grant award of $386,617 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) aims to develop safer and more efficient chemical methods for the synthesis of complex, fluorinated, and highly functional pharmaceutical compounds. The key research areas encompass: (1) electromicellar catalysis for the formation of fluorinated heterocycles, allenes, and reactive intermediates; (2) enantioselective...
- This federal Project Grant award for $678,000.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to understand the molecular mechanisms governing the assembly of eukaryotic ribosomes. The research aims to define the co-transcriptional assembly events and transitions towards stable post-transcriptional nucleolar assembly intermediates of ribosomal subunits, leveraging advanced...
- This federal Project Grant award of $459,250.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to develop a systematic approach for detecting regulatory RNAs and their functional motifs based on RNA-protein interactions. The key research objectives include: Investigating whether RNA regulates the genomic occupancies of chromatin-associated proteins (CAPs). Employing an...
- This federal Project Grant award, valued at $456,500.00 and provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), is focused on decoding the biosynthetic logic of modular polyketide synthases (PKSs). PKSs are enzymatic assembly lines that produce complex small molecules with medicinal importance, such as antibiotics, anticancer agents, and lipid-lowering statins. The key objectives of this research...
- This federal Project Grant award for $647,301 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to advance the understanding of iron-sulfur enzymes. The key objectives are to: Develop synthetic models of iron-sulfur enzyme active sites to characterize their molecular-level structures and reaction mechanisms, and Improve spectroscopic methods for analyzing the complex iron-sulfur clusters...
- This $244,450 Project Grant, awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to understand the catalytic mechanisms, structural dynamics, and biomedical importance of two key classes of metalloenzymes: matrix metalloproteinases (MMPs) and iron(II)/2-oxoglutarate (2OG)-dependent oxygenases. The project, spanning July 2025 to June 2030, aims to provide missing knowledge on these...
This federal Project Grant award of $427,016.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the "Synthesis and Biochemical Evaluation of Ruthenium Compounds" research project at Bard College. The primary aims of this 3-year project are to synthesize and characterize ruthenium-based compounds, investigate their binding to various RNA molecules, and determine if the compounds can inhibit the dihydrofolate reductase (DHFR) enzyme. The research seeks to develop ruthenium complexes with enhanced binding to nucleotides, improved solubility, and activity against diseases like diabetes, bacterial infections, and cancer. The project will advance fundamental scientific understanding of ruthenium compounds as potential therapeutic agents targeting different biomolecules beyond just DNA and proteins.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $427.0k | 8/25/25 |