This National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) Project Grant award of $613,746 to Osem Fluidics Inc. aims to develop 3D-printed microfluidic channel architectures to precisely control the structure and properties of lipid nanoparticles (LNPs) for enhanced nucleic acid delivery. The research focuses on designing, simulating, and testing various 3D channel configurations to manipulate flow conditions and tailor LNP...
This $457,390 Project Grant award from the National Science Foundation's (NSF) Division of Materials Research aims to develop a new mRNA delivery system based on functional phosphoserine (PS) lipids. The award will support research to understand the targeted and immunomodulatory properties of these zwitterionic functional materials for mRNA delivery, with potential applications in gene therapy, protein-replacement therapy, and cancer immunotherapy. Key objectives include enhancing mRNA...
This Project Grant award from the National Institutes of Health's National Institute of General Medical Sciences (CFDA 93.859 Biomedical Research and Research Training) supports research to determine whether systems-based modeling can accurately predict the impact of lipids in oral delivery systems and food on the absorption of orally delivered compounds. The $930,000 award to Northeastern University, with a period of performance from September 1, 2024 to June 30, 2029, aims to reveal the...
This $440,327 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) supports research to uncover the key factors and mechanisms involved in lipoprotein trafficking to the bacterial outer membrane in Gram-negative bacteria. The primary objectives are to identify the additional lipoprotein trafficking pathways that exist beyond the known Lol pathway, understand how distantly related...
The Project Grant award, ID R35GM157060, was made by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award, totaling $381,995, will support research at the University of North Carolina at Chapel Hill (UNC-CH) to investigate and manipulate cells in low oxygen environments using lipid nanoparticles. The research will focus on two main areas: (1) conducting comparative analyses to understand how low oxygen...
This $381,616 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to develop design rules for polyelectrolyte complex micelles (PCMs) - a unique class of self-assembled nanoparticles for delivering hydrophilic payloads such as nucleic acids. The primary goals are to: 1) establish structure-property relationships between polymer/nucleic acid structure and PCM assembly, physical...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), aims to develop novel non-viral gene delivery methods that are less expensive and safer than lentiviral vectors for cell therapies. The $364,167 award, spanning from Sep 1, 2024 to Aug 31, 2027, supports a collaborative research effort led by Villanova University. The key objectives are to: 1) develop novel polymeric gene delivery...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $302,605 to Chimerna Therapeutics, Inc., a biotechnology company in New York, NY, for a research project focused on developing scalable and low-cost methods to produce site-specifically labeled circular RNAs (circRNAs). The key objectives are to: Optimize a bacterial expression system for high-efficiency amino...
This federal Project Grant award, valued at $382,801 and awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), aims to develop a new class of artificial RNA-based condensates as customizable organelles for use in living cells. The key objectives are: Optimizing the sequence and structure of RNA "nanostars" to produce condensates with tailored thermodynamic and biophysical properties, as well as...
This $545,162 Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), seeks to develop a modular arsenal of protein and lipid hybrid biomaterials for delivering short interfering RNA (siRNA) sequences. The key objectives are to: Expand a library of cationic supercharged protein sequences to enhance endosomal escape and siRNA binding...