Project Grant R15GM157720
Award Date 9/8/25
Completion Date 8/31/28
Dollars Obligated $385K
Funding Federal Agency
Awarding Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
Kalamazoo, MI 49006, USA
Similar Awards
- This federal Project Grant award of $146,816.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports research to develop general strategies for the biocatalytic synthesis of N-N and C-N heterobiaryl atropisomers, a class of medicinally relevant chiral compounds that are difficult to obtain through other methods. The research outlined will employ bioinformatic techniques to...
- The federal Project Grant award of $420,066.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will fund research to systematically characterize how regulatory networks control secondary metabolism in microbes. The project aims to use genome-wide screens and multi-omics approaches to predict and access the unexplored biosynthetic potential of microbes, with the goal of accelerating the discovery,...
- This $118,242 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training federal grant program (CFDA 93.859), supports the development of a new class of proximity-inducing compounds termed Group-Transfer Chimeras for Inducing Proximity (GRIPS). The research aims to expand GRIPS into a modular platform that can rapidly recruit and target kinases for controlled cellular signaling and protein editing, with potential...
- This federal Project Grant award of $390,000.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research on the structural dynamics of G protein-coupled receptor (GPCR) oligomerization and its impact on cellular localization and signaling. The 5-year award, effective August 1, 2025, will fund investigations into the complexes formed between GPCRs, G proteins, β-arrestins, and GPCR kinases,...
- This federal Project Grant award, valued at $427,625.00 and provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research on the conformational dynamics and regulatory mechanisms of the KCNH family of ion channels. The research aims to examine the voltage sensor domain and S4 helix of KCNH channels to measure their structural changes during channel opening and closing. The project will...
- This Project Grant award of $407,750.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to elucidate the allosteric mechanisms of two key enzyme systems - glutamate racemases (GR) and executioner caspases-7 (C7). These enzymes are validated drug targets for antimicrobials and Parkinson's/inflammatory diseases, respectively. The research employs experimental and computational approaches...
- This federal Project Grant award of $123,737.00 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to advance drug discovery for protein domains containing intrinsically disordered regions. The award was granted to the Regents of the University of Michigan, a prominent U.S. state government-owned educational institution, with a performance period from October 1, 2024 to April 30, 2025. The NIGMS...
- This Project Grant award, valued at $417,243 and funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports the synthesis of homogeneous proteoglycan-like glycopeptide and glycoprotein libraries for microarray studies. The goal is to develop innovative chemical, chemoenzymatic, and chemoselective ligation strategies to produce well-defined proteoglycan structures, which will then be incorporated into...
- This federal Project Grant award of $525,436.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research on the structural pharmacology of GIRK channel disease mutants. The research aims to elucidate the molecular mechanisms underlying the loss of potassium selectivity and constitutive activation of GIRK2 channels associated with Keppen-Lubinsky syndrome, a...
- This federal Project Grant award of $442,710, awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), is focused on characterizing novel lanthipeptide natural products from marine bacteria. The objective is to structurally elucidate the lanthipeptide compounds produced by two biosynthetic gene clusters identified in an ecologically important marine bacterial species, test their antibiotic potential against...
This federal Project Grant award, valued at $384,609.00 and provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to design, synthesize, and characterize novel 5-hydroxy-2-(3-phenylpropyl)chromone analogues as selective and potent 5-HT2B receptor antagonists with improved neuroprotective activity against glutamate-induced excitotoxicity. The research, conducted by Kalamazoo College, aims to develop new compounds that can prevent glutamate excitotoxicity, a common pathology in various neurodegenerative disorders. The project period runs from September 8, 2025 to August 31, 2028.
Generated 10/21/25, 6:31 AM
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $384.6k | 9/8/25 |