Project Grant R15GM154270
- The National Institute of General Medical Sciences (NIGMS) has awarded a $424,231 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the Augusta University Research Institute, Inc. in Augusta, Georgia. The objective of this 3-year project is to understand the fundamental mechanisms and functions of enzymes that catalyze the homologation (insertion of a methylene group) of amino acids in natural product biosynthesis. The research aims to determine the...
- This Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to understand how mutations in the asparagine synthetase (ASNS) enzyme linked to asparagine synthetase deficiency (ASNSD) impact protein dynamics and catalytic activity. The $417,498 project, with a period of performance from Sep 1, 2025 to Aug 31, 2030, aims to use enzyme kinetics, hydrogen-deuterium...
- This $440,999 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to examine the structure and function of ornithine decarboxylase antizyme (OAZ) RNA, a polyamine sensor, from various organisms. The project aims to: (1) evaluate the specificity and affinity of polyamine binding to OAZ RNAs, (2) investigate the 3D structure of OAZ RNAs, and (3) explore the role of OAZ RNAs...
- This $600,000 Project Grant awarded by the U.S. Department of Agriculture's National Institute of Food and Agriculture (AFRI program, CFDA 10.310) aims to identify the specific antimicrobial molecules produced by the beneficial bacterium Pseudomonas protegens PBL3 and understand how they inhibit the growth of a pathogenic bacterium that causes a devastating disease in rice crops. The goal is to develop biologically-based solutions to control crop diseases and reduce losses, thereby alleviating...
- This $457,088 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of imaging tools to improve the activity of endolysins, a promising alternative to traditional antibiotics for treating antibiotic-resistant bacterial infections. The key products and services to be delivered include: Synthesizing a panel of internally quenched substrates to assess the activity of...
- The federal Project Grant award of $420,066.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will fund research to systematically characterize how regulatory networks control secondary metabolism in microbes. The project aims to use genome-wide screens and multi-omics approaches to predict and access the unexplored biosynthetic potential of microbes, with the goal of accelerating the discovery,...
- This $299,322 Project Grant award to Auburn University was issued by the USDA National Institute of Food and Agriculture (NIFA) under the Agriculture and Food Research Initiative (AFRI) program (CFDA 10.310). The objective is to determine the impact of antimicrobial use (AMU) in poultry production on microbial diversity, antimicrobial resistance (AMR) genes, and horizontal gene transfer in the environment. The research will compare AMR levels and animal health outcomes between antimicrobial-free...
- This $412,632 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to advance the biocatalytic synthesis of complex medicinal small molecules. The award, with a performance period from August 1, 2025 to July 31, 2030, will fund the development of computer-aided synthesis planning (CASP) tools to generalize known enzymatic reactions and predict routes for producing...
- This Project Grant awarded by the U.S. Department of Agriculture's National Institute of Food and Agriculture (NIFA) under the Agriculture and Food Research Initiative (AFRI) program (CFDA 10.310) will establish proof-of-concept for using lettuce as a platform to produce and deliver next-generation oral biologics. The $280,305 award to Arkansas State University (A-State) aims to test new ways of engineering lettuce to produce protein-based medicines that are protected during digestion and...
- This $930,000 Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) is focused on advancing the understanding of transcription fidelity mechanisms in eukaryotic RNA polymerases. The project at the University of Alabama at Birmingham (UAB) will employ transient state kinetic approaches to quantify the differences in transcription and error correction mechanisms across the three eukaryotic RNA polymerases (I, II, and III). This research aims...
This Project Grant award of $403,640 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to express and characterize high-activity, high-specificity microbial L-asparaginases from naturally occurring microorganisms in the Alabama Black Belt region. The goal is to develop L-asparaginases for inhibition of acute lymphoblastic leukemia cell proliferation and reduction of acrylamide formation in heat-processed foods. The award recipient, Auburn University Montgomery, will screen microorganisms from the Alabama Black Belt, partially purify L-asparaginases from promising isolates, and characterize their enzymatic properties. Genome sequencing will identify L-asparaginase genes in the selected microorganisms, which will then be expressed and further assessed. This research aims to identify novel L-asparaginases with potential pharmaceutical and food processing applications.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $403.6k | 9/5/25 |