Project Grant R15GM152945
Award Date
9/22/23
Completion Date
9/20/26
Dollars Obligated
$409K
Federal Agency
National Institute of General Medical Sciences
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Oregon, USA
Similar Awards
This $153,656 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to understand how post-translational modifications, specifically ubiquitin, contribute to kinetochore assembly and function in the budding yeast Saccharomyces cerevisiae. The goal is to generate a comprehensive map of kinetochore regulation by the Mub1/Ubr2 E3 ubiquitin ligase complex and investigate how...
This federal Project Grant award of $126,311.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) to investigate the mechanisms of heterochromatic transcriptional gene silencing. The research aims to elucidate how heterochromatin, a form of condensed chromatin, represses transcription by RNA polymerase II. Specific objectives include identifying the necessary functions of the heterochromatin...
This federal Project Grant award for $438,629 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to characterize fundamental mechano-molecular mechanisms of cell division. The research aims to investigate the functional contributions of extremely large intrinsically disordered regions in proteins at the kinetochore and perichromosomal layer, as well as study the regulation of branching microtubule...
This National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) Project Grant award of $396,760 supports research to elucidate how the Chromosome Passenger Complex (CPC) is localized and activated at the spindle midzone, which is critical for directing cell division and preventing aneuploidy. The research, conducted by The General Hospital Corporation (doing business as Massachusetts General Hospital), aims to determine the intrinsic...
This $361,250 project grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to determine the multifunctional roles of proteins involved in animal development and human health. The project aims to investigate the secondary functions of the abnormal spindle (Asp) protein, whose human ortholog (ASPM) has been implicated in microcephaly, cancer, and infertility. The research will leverage...
This federal Project Grant award of $402,500 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) is supporting research to investigate the biology of supernumerary chromosomes using the B chromosome model system in Drosophila melanogaster. The key objectives are to: Map the sequence context of the B chromosome to understand the genetic environment enabling its formation from essential chromosomes. Assess how...
This Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under CFDA Program 93.859 - Biomedical Research and Research Training, supports research to understand how sumoylation (a post-translational modification process) regulates ribosome biogenesis, a critical cellular process for cell growth and proliferation. The 5-year, $1,560,000 award to Oregon Health & Science University aims to investigate the mechanisms by which the enzymes USP36 and SENP3...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) provides $180,500.00 to St. John's University, New York to investigate the genetic regulation of sperm activation and development in the nematode C. elegans. The research aims to understand the molecular mechanisms by which specific phosphatase enzymes regulate the transformation of spherical spermatids into motile,...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under CFDA program 93.859 Biomedical Research and Research Training, is focused on studying the regulation of PPM family serine/threonine phosphatases. The $393,149 award will support research to uncover mechanistic principles of how these phosphatases are controlled, with a focus on understanding how bacterial phosphatase regulation features contribute to the control of human phosphatases,...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) provides $254,919 to the University of California, San Diego (UCSD) from February 1, 2025 to January 31, 2030. The overarching goal of the research is to understand the regulatory mechanisms that ensure accurate transmission of the genome during cell division. The project will investigate two main areas: 1) how post-translational...