This $379,504 Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program supports research at the University System of New Hampshire's Keene State College to investigate the long-term, tissue-specific effects of chronic arsenic exposure.
The overarching goal is to establish functional links between gene expression and phenotypic manifestations in response to transgenerational arsenic exposure in the model organism Daphnia. Specifically, the researchers aim to: 1) detect tissue-specific arsenic accumulation patterns using laser-ablation-ICP-MS, 2) identify tissue-specific gene expression changes via RNA sequencing and comparative genomics, and 3) validate conserved genetic biomarkers of arsenic toxicity in mammalian cell lines. This work is expected to advance the understanding of the mode of action for arsenic and other environmental toxicants, potentially leading to more effective mitigation strategies for vulnerable human populations.
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