Project Grant R15DK139519

Award Date 9/15/24
Completion Date 8/31/27
Dollars Obligated $319K
Federal Grant Program
93.847
Assistance Type
Project Grant
Place of Performance
Valparaiso, IN, USA
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This federal Project Grant award of $318,554.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) will support research at Valparaiso University to investigate the regulation of chloride-driven fluid secretion and its subversion by the fungal pathogen Candida albicans.

The key objectives of this 3-year research project are to: 1) determine the role of the hormone 17-β estradiol in regulating the yeast-to-hypha morphological shift in C. albicans, 2) elucidate the post-translational mechanisms leading to internalization of the NKCC1 chloride transporter and its fate in the endocytic pathway, and 3) demonstrate how C. albicans subverts the PKC-mediated NKCC1 internalization to inhibit chloride-based fluid secretion, a key host defense mechanism. This research aims to advance the understanding of the cellular events surrounding C. albicans gut infection and inform the development of improved therapies for invasive candidiasis.

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