This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), is focused on developing a novel high-throughput, high-content imaging platform for analyzing extracellular vesicles (EVs) at the single-particle level. The $298,999 award to Numentus Technologies Inc. will fund the construction, testing, and application of this platform to detect and characterize EV subpopulations, including...
This $516,355.74 Project Grant from the National Cancer Institute, part of the Department of Health and Human Services, aims to develop new technologies for immunotherapy monitoring and liquid biopsy through the Cancer Research Manpower federal grant program. Specifically, the Massachusetts General Hospital will utilize the funding to create an ultra-high sensitive platform that can map single extracellular vesicles to parent cells at the single particle level and apply it to profile tumor...
This federal Project Grant award from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research program (CFDA 93.394) provides $427,095 to Northeastern University to develop a novel microfluidic droplet-based platform (MDP) technology. The MDP will generate and analyze a 3D biomimetic multicellular immunogenic tumor model to: Establish multiple levels of hypoxia within the same tumor-chip for parallel processing. Investigate spatiotemporal interaction between the...
This federal Project Grant award for $576,716.86 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) supports research and development of advanced technologies for characterizing extracellular vesicles (EVs) to improve ovarian cancer detection and monitoring. The award to Northwestern University aims to combine machine learning-enabled inverse design...
This Project Grant award of $231,413 from the National Cancer Institute's Cancer Detection and Diagnosis Research program (CFDA 93.394) aims to develop a novel SPINEX (Separation-Processing Integration for Extracellular Vesicles) technology to streamline sample preparation for extracellular vesicle (EV) analysis. The project, awarded to The General Hospital Corporation (doing business as Massachusetts General Hospital), has two key objectives: Implement a fully automated, multi-functional SPINEX...
This federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) to the Sloan-Kettering Institute for Cancer Research provides $577,034 in funding to investigate the interplay between the physical properties of the tumor microenvironment and the ability of cytotoxic lymphocytes to recognize and destroy cancer cells. The research will examine how distinct metastatic microenvironments (e.g. rigid bone, soft lung) affect the biomechanics of cancer cells...
This Project Grant award, with the Federal Grant Award ID R01CA286786, was provided by the National Cancer Institute under the Cancer Detection and Diagnosis Research program (CFDA 93.394). The award totaling $702,729.00 was granted to Michigan State University to develop an extracellular vesicle-mediated targeted microRNA delivery system for EGFR cancers. The project aims to engineer cell-derived extracellular vesicles (EVs) with antibody mimetics to target EGFR-positive cancer cells and...
This federal Project Grant award from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) supports the development of a new bio-orthogonal mid-infrared photothermal imaging approach to quantitatively measure various molecular events in cancer cells at the subcellular level. The $407,113 award to Trustees of Boston University will be used to: 1) build a library of nitrile-based probes to sense important molecular events inside cancer cells; 2) develop...
This federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), supports the development of extracellular vesicles (EVs) as therapeutic carriers. The $622,000 award, effective August 1, 2024 through July 31, 2027, will enable researchers at The Washington University in St. Louis to engineer endothelial cell-derived EVs to efficiently...
This Project Grant award from the National Cancer Institute (CFDA 93.398 Cancer Research Manpower) provides $137,322 to Trustees of Boston University to develop disulfated polyamidosaccharide (DISULPAS) nanoparticles for the targeted delivery of chemotherapeutics to metastasizing cancer cells. The goal is to create a synthetic fucoidan mimetic that can more consistently bind to the P-selectin protein, which is upregulated on many tumor cells and plays a key role in metastasis. The project will...