Project Grant R15AR085911
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded The Regents of the University of California at Riverside $224,100 on September 15, 2025, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate epigenetic factors controlling epidermal stem cell longevity in adult skin. The research examines how epigenetic regulators, specifically polycomb repressive complexes, function in hair follicle stem cells and interfollicular...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded the University of Texas Southwestern Medical Center $578,211 on August 7, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to fund investigator-initiated research defining how epidermal NADPH depletion and redox imbalance disrupt skin barrier function and drive systemic metabolic effects. The project addresses the physiological roles of NAD kinase (NADK) and NADPH...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded Icahn School of Medicine at Mount Sinai $551,321 on July 1, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate the cellular and molecular mechanisms governing dermal condensate formation during embryonic hair follicle development. The research explores how axon guidance signaling regulates the migration and clustering of dermal papilla cell progenitors...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded New York University $148,062 on September 30, 2025, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The funded research investigates the mechanism by which epithelial stem and progenitor cells encode inflammatory memory in psoriasis and other remitting-relapsing inflammatory disorders. The study tests whether homeostatic and inflammatory transcription factors dynamically...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded The University of Chicago $1,573,208 on July 15, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate immunomodulatory functions of epithelial stem cells during wound repair. The research addresses delayed or defective wound healing in aged and chronically ill populations by examining how epithelial stem cells in the epidermis and hair follicles modulate...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded the University of Texas Health Science Center at Houston $623,286 on July 1, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate hypoxia-driven NUDT21-mediated alternative polyadenylation in lung and skin fibrosis associated with systemic sclerosis. The project, designated R01AR087804, examines how tissue hypoxia—driven by Raynaud's phenomenon and...
- Federal Grant Award Summary New York University School of Medicine received a $1.92 million Project Grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), effective September 1, 2025, through August 31, 2028. This research project investigates the plasticity of melanocyte stem cells (MCSCs) and mature melanocytes (MCs) within adult hair follicles, specifically examining...
- The National Institute on Aging awarded Northwestern University $559,795 on May 1, 2026, under the Aging Research program (CFDA 93.866) to investigate how cell mechanics regulate hair follicle stem cells during homeostasis and aging. The research examines microRNA-205-mediated regulation of the extracellular matrix and actin cytoskeleton to understand hair follicle stem cell quiescence and activation, with particular focus on leveraging microRNA-205 to enhance stem cell function in aging. The...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded $123,108 to The University of Texas Southwestern Medical Center on April 8, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), to support Dr. Tamia Harris-Tryon's K24 mentoring career development award in translational research focused on inflammatory skin disease. Dr. Harris-Tryon, an Associate Professor in the Department of Dermatology at UT Southwestern, leads research...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded the University of Texas Health Science Center at Houston $156,000 on July 1, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The project investigates pulmonary arterial hypertension susceptibility in systemic sclerosis patients carrying the DNASE1L3 R206C genetic variant. Aim 1 will assess the impact of chronic DNASE1L3 deficiency on the pulmonary vasculature in mice...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded Texas Woman's University $475,063 on August 1, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award funds research into vitamin A metabolism and its regulation of the hair follicle stem cell cycle, with specific focus on sex-dependent mechanisms. The research examines how sex hormones and exogenous retinoids alter endogenous retinoic acid synthesis within the hair follicle stem cell niche to maintain stem cell quiescence and prevent hair aging and loss. Work includes identifying vitamin A metabolism and signaling cross-talk between sex hormones and retinoic acid pathways, evaluating how these interactions affect hair follicle stem cells during aging, and investigating the dual role of retinoids in preventing cutaneous squamous cell carcinoma while addressing sex differences in hair loss and aging. Performance occurs in Denton, Texas through July 31, 2029. The research uses the hair cycle as an in vivo model for stem cell regulation, with objectives addressing the central hypothesis that sex hormones regulate retinoic acid synthesis to maintain hair follicle stem cell quiescence and prevent hair aging. This is a Project Grant assistance award.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $475.1k | 7/28/26 |