Project Grant R15AI203247
- The National Institute of Allergy and Infectious Diseases, part of the Department of Health and Human Services, awarded $571,412 to the University of Maryland, College Park on June 11, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds research into the regulation of bacterial physiology and infections through linear diribonucleotides and RNA degradation. The project will characterize how diribonucleases and triribonucleases bind their respective...
- The National Institute of Allergy and Infectious Diseases, within the Department of Health and Human Services, awarded The Ohio State University $354,416 on February 2, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds research into novel peroxisome functions in Histoplasma capsulatum pathogenesis. The research will define the peroxisome proteome and metabolome in pathogenic-phase fungal cells to uncover new peroxisomal roles beyond known functions...
- The National Institute of Allergy and Infectious Diseases, part of the Department of Health and Human Services, awarded the University of Washington $1,343,164 on July 17, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds research into asymptomatic tuberculosis transmission, infectiousness, and immunology conducted in Nairobi, Kenya. The research investigates the infectiousness spectrum of asymptomatic TB, identifies risk factors for increased...
- The National Institute of Allergy and Infectious Diseases awarded Baylor College of Medicine $752,172 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct a mechanistic study of an RNA translocase via integrative multi-resolution approach. The research investigates how mycobacteria persist in the host by examining a conserved bifunctional RNA helicase and nuclease enzyme found across mycobacterium species. The enzyme is thought to promote...
- The National Institute of Allergy and Infectious Diseases awarded The Rockefeller University $798,670 on June 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop bioinformatics-guided methods for discovering novel antibiotics from previously inaccessible microbial sources. The project couples direct nanopore metagenomic sequencing with synthetic bioinformatic natural products discovery methods to identify complete biosynthetic gene clusters from...
- The National Institute of Allergy and Infectious Diseases awarded University of Massachusetts Medical School $139,968 on September 30, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the relationship between genetic variants, transcriptional responses, and Mycobacterium tuberculosis infection outcomes in macrophages derived from genetically diverse Collaborative Cross mice. The research explores how polymorphisms such as those in the STAT2 locus...
- The National Institute of Allergy and Infectious Diseases awarded the University of Massachusetts $797,682 on July 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop and apply chemical tools for investigating the structure and function of the mycobacterial outer membrane and its remodeling under stress and host interaction. The award funds research to address knowledge gaps in mycobacterial membrane glycan and lipid biology, which have historically...
- The National Institute of Allergy and Infectious Diseases awarded Duke University $171,269 on November 1, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the role of the RGS12 locus in macrophage function. The research uses the zebrafish-Mycobacterium marinum model and human tuberculosis patient cohort datasets to examine how RGS12B regulates macrophage epithelioid transformation and granuloma bacterial containment. Preliminary data indicate that...
- The National Institute of Allergy and Infectious Diseases awarded the Board of Regents of the University of Nebraska, through its University of Nebraska Medical Center division, $586,920 in project grant funding on June 15, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The recipient will conduct research on pyruvate acquisition by Staphylococcus aureus in intracellular environments. The work characterizes the regulation and physiological roles of bacterial...
- The National Institute of Allergy and Infectious Diseases awarded Health Research, Inc. (Wadsworth Center Division) $403,756 on April 14, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to map the determinants of bedaquiline resistance in Mycobacterium tuberculosis. The recipient will use saturating mutagenesis to create a comprehensive database of loss-of-function mutations in the MMPR gene (RV0678) that confer bedaquiline resistance. The database will enable...
The National Institute of Allergy and Infectious Diseases awarded The University of Akron $538,741 on August 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct structure and function studies of orphan cytochrome P450 enzymes CYP126A1 and CYP143A1 from Mycobacterium tuberculosis. The research will employ resonance Raman spectroscopy and biochemical analysis to define the structural features of reactive intermediates governing CYP126A1 catalysis, elucidate structural factors determining inhibitory potency of azole-based drug candidates against both enzymes, and identify potential substrate-like ligands of CYP143A1 through high-throughput screening coupled with spectroscopic and biochemical characterization. These findings are intended to establish a foundation for rational design of next-generation antitubercular agents targeting P450-mediated pathways. The award supports research at The University of Akron, Akron, Ohio, with a period of performance from August 1, 2026, through July 31, 2029. The assistance type is a Project Grant. This is a competitive research award under NIH's program to support biomedical research and research training in infectious diseases and related areas at public and private nonprofit institutions.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $538.7k | 7/28/26 |