Project Grant R15AI199958
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Ohio State University a Project Grant of $439,094 on April 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate transcriptional regulatory mechanisms controlling exopolysaccharide (EPS) biosynthesis in Pseudomonas aeruginosa. The two-year research initiative, concluding March 31, 2028, focuses on understanding how this opportunistic pathogen...
- Federal Project Grant Award Summary The Ohio State University has received a $670,881 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded April 1, 2026, with completion targeted for March 31, 2031. The grant funds research investigating how the intracellular bacterium Anaplasma phagocytophilum (APH), which causes human granulocytic anaplasmosis (HGA)—a leading tickborne disease by...
- Federal Grant Award Summary The Ohio State University received a $354,416 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded February 2, 2026, with completion targeted for January 31, 2028. The research project, "Non-Siderophore Function of Peroxisomes in Histoplasma Pathogenesis," investigates novel peroxisome functions that enable the fungal pathogen Histoplasma...
- Federal Project Grant Award Summary The University of South Florida received a $470,953 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective August 1, 2025, through July 31, 2030. This five-year research initiative will produce biomedical research and scientific knowledge concerning the role of SSR42, a regulatory RNA molecule, in virulence factor regulation and pathogenic...
- Federal Project Grant Award Summary Award Details: The National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) awarded The Ohio State University $758,645 on February 2, 2026, for a five-year project extending through January 31, 2031. The project investigates the clearance of gut-derived lipopolysaccharide (LPS) endotoxin by hepatic stabilin receptors, with the goal of developing therapeutic interventions for...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Ohio State University a Project Grant of $433,125 under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct basic research on influenza A virus (IAV) pathogenesis and acute respiratory distress syndrome (ARDS) mechanisms. The two-year research initiative, awarded July 2, 2025, and extending through June 30, 2027, investigates how the viral PB1-F2 protein...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Ohio State University a Project Grant totaling $787,498 (awarded February 19, 2026, with completion targeted for January 31, 2031) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The research project, titled "Intrinsic STING Signaling Shapes Phagocytosis-Dependent Innate Immunity," delivers scientific investigation into the mechanisms by which...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Ohio State University $433,125 under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective July 1, 2026, through June 30, 2028. This Project Grant supports research examining the subcellular proteome response to influenza infection in intact human lung tissue. The research team will characterize and optimize adeno-associated virus (AAV) vectors for transduction of...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Ohio State University a $525,789 Project Grant effective April 1, 2026, through March 31, 2031, under the Allergy and Infectious Diseases Research program (CFDA 93.855). This research initiative identifies bacterial isolates and microbial communities that influence male life history traits and mating success in genetically diverse Aedes aegypti mosquitoes to enhance sterile insect...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Ohio State University a Project Grant of $537,861 under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective August 1, 2025, through July 31, 2030. This grant supports the development and advancement of pairwise survival analysis statistical methods for studying infectious disease transmission within households and close-contact groups. The research extends existing...
Ohio University received a $563,035 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective September 1, 2026 through August 31, 2029. The award supports research to decipher the unique and independent roles of alpha phenol soluble modulin (aPSM) peptides and the aPSM transcript in Staphylococcus aureus pathogenesis. This work addresses critical gaps in understanding how individual aPSM peptides—amphipathic, alpha helical peptides approximately 22 amino acids in size—contribute to specific bacterial phenotypes including cell lysis, biofilm development, extracellular vesicle production, immune activation, and virulence. The research comprises two primary aims. Aim 1 investigates the specific biological function of each individual aPSM peptide by utilizing individual mutants rather than complete knockouts, thereby determining which phenotypes are associated with specific peptides. Aim 2 tests a novel hypothesis that the aPSM transcript functions as a regulatory RNA in addition to encoding peptides. The findings are expected to advance understanding of community-acquired methicillin-resistant S. aureus (CA-MRSA) virulence mechanisms and may inform therapeutic strategies targeting this significant human pathogen.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $563.0k | 7/10/26 |