This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $515,282 to Case Western Reserve University (CWRU) to conduct research aimed at better understanding the molecular mechanisms of HIV spread through cell-to-cell contact. The key objectives are to: 1) identify determinants and composition of the virological synapse (VS), a specialized structure formed between...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to enhance the understanding of ADP-ribosylation (ADPR) and its role in HIV-1 latency and reactivation. The $285,816 award, spanning from September 2024 to October 2027, will fund research to identify global proteomic changes to ADPR during HIV-1 latency and reactivation, investigate PARP-HIV-1 interactions in...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under CFDA Program 93.855 - Allergy and Infectious Diseases Research, provides $229,163.00 to investigate the function of the HIV-1 envelope (Env) cytoplasmic tail domain and how it impacts Env trafficking and viral transmission. The research aims to determine if a truncated Env variant with a C-terminal di-cys motif is lipidated, enabling it to traffic to viral budding sites and viral synapses,...
This $220,224 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports computational research on the assembly, maturation, and uncoating processes of the HIV-1 virus. The University of Chicago, the grant recipient, will investigate factors beyond the viral capsid that influence critical morphological transitions in the HIV-1 life cycle, such as the role of host cell factors and...
This federal Project Grant award, provided by the National Institute of Allergy and Infectious Diseases under the Allergy and Infectious Diseases Research program (CFDA 93.855), will support research on the role of defective HIV proviruses and their impact on persistent innate immune activation. The $765,274 award, with a project period running from Aug 22, 2024 to Jun 30, 2029, will investigate mechanisms by which HIV-infected CD4+ T cells and macrophages harbor defective proviruses that...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), is funding research to characterize the HIV latent reservoir and understand the mechanisms driving its persistence in people living with HIV on antiretroviral therapy. The $234,115 award will support in-depth sequencing of intact and defective HIV proviruses to map the clonal distribution of infected cells, as well as...
The federal Project Grant award of $500,000 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) aims to identify and modulate molecular pathways that govern T cell antigen sensitivity in persons with HIV. The primary objectives are to: 1) Elucidate regulatory mechanisms governing antigen-refractory HIV-specific CD8+ T cells, 2) Define the contributions of HIV-infected antigen-refractory CD4+ T cells to...
This federal Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), is supporting a study of acute HIV infection to investigate strategies for HIV eradication. The $794,045 award to The Regents of the University of California, San Francisco (UCSF) aims to identify host cellular mechanisms that drive HIV reservoir decay and sustained viral control, with the goal of informing...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $859,992 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to Yale University to conduct research into the molecular mechanisms underlying HIV-1 maturation and the impact of inhibitors on this process. The research is structured around two specific aims: 1) Determining the high-resolution structural pathway of HIV-1 Gag assemblies and capsid during maturation within their native cellular...
This $820,845 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to New York University School of Medicine will support a collaborative research project with the Shelby County Health Department to inform policy decisions for improving HIV outcomes across diverse settings. The project will use mathematical modeling to simulate ways to optimize the distribution of interventions, such as long-acting...