This is a Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), part of the Allergy and Infectious Diseases Research program (CFDA 93.855). The $207,225 award supports research to investigate how the bacterium Chlamydia trachomatis manipulates cellular pathways, specifically the PICALM protein, to maintain a "silent" infection within the host cell. The goal is to better understand how Chlamydia utilizes host cell nutrient trafficking to promote its...
This Project Grant award, ID R21AI178108, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The $617,000 grant, awarded on August 21, 2024, supports research led by The University of Kentucky Research Foundation to investigate the role of putative cytotoxins in Chlamydia infection. The researchers aim to apply genetic and biochemical approaches to delineate the molecular functions of these...
This Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 Allergy and Infectious Diseases Research, provides $423,500.00 to The University of Kentucky Research Foundation to investigate the role(s) of chlamydial polymorphic membrane proteins (PMPs) during infection with Chlamydia trachomatis. The research aims to delineate the specific function(s) of the PmpI protein during different stages of the chlamydial developmental cycle, as...
This federal Project Grant award of $130,950 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research at the University of Idaho to understand the developmental cycle of Chlamydia bacteria at the single-cell level. The key objectives are to: 1) Develop a CRISPR-based knockdown screen to assess the role of essential genes in regulating Chlamydia cell type function and the developmental...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $782,795 to the University of Tennessee Health Science Center in Memphis, TN to conduct research on the regulation of cell division in the bacterial pathogen Chlamydia trachomatis. The research aims to define the molecular mechanisms that regulate the unique polarized division process of Chlamydia, which lacks several proteins essential for...
This Project Grant award, with a total funding amount of $431,750, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The funding will support a 2-year developmental project at the University of California, Irvine to advance immunological research tools for studying the white-footed deermouse (Peromyscus leucopus), a natural reservoir for zoonotic agents like Lyme disease, anaplasmosis, and...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $390,000 to the Regents of the University of Idaho to study the developmental cycle of Chlamydia bacteria at the single-cell level. The award supports two research aims: 1) developing a CRISPR interference screen to assess the role of essential genes in regulating Chlamydia cell types, and 2) determining the spatial...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $226,204 to the University of Maryland, Baltimore to investigate the vaginal microbiome and immune response factors that contribute to the spontaneous clearance of Chlamydia trachomatis (CT) infections in women. The key objectives are to: (1) evaluate species- and strain-specific vaginal bacterial growth rates, (2)...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $466,725 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of South Carolina. The 5-year grant, effective June 1, 2025 through May 31, 2030, will enhance the utility of deer mice as an infectious disease model. Specifically, the funding will: (1) strengthen the breeding capacity of the university's Peromyscus Genetic Stock Center, (2) develop Peromyscus-specific...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $2,151,847 Project Grant under CFDA 93.855 Allergy and Infectious Diseases Research to The Johns Hopkins University. The 5-year grant, awarded on August 1, 2024, supports research to investigate the function of the transcription factor BACH1 as a novel pioneering repressor in macrophages, and its impact on macrophage homeostasis and inflammation. The research aims to provide mechanistic insights into how BACH1...