Project Grant R15AI124156

The Applied Research Foundation of West Virginia received a $444,000 Project Grant from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research program) to study the effects of stress on Chlamydia infections in a mouse model. The research aims to define the mechanisms by which stress may suppress the immune system and increase the intensity of Chlamydia genital infection and its associated immunopathologies. Key aspects of the project...

This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $248,999.00 in funding to Colorado State University (CSU) for research on the mechanisms of temperature-sensitive meiotic chromosome structures in male infertility. The research aims to exploit the model organism Caenorhabditis elegans to investigate how sexual dimorphisms in the...

This five-year, $813,838 project grant from the National Institute of Allergy and Infectious Diseases will fund research into the genetic and hormonal mechanisms underlying sex differences in tuberculosis (TB) and TB-HIV coinfection. The Johns Hopkins University will investigate how X chromosome complement and sex steroid hormones impact TB pathogenesis using cellular models, animal studies, and human samples. Researchers will utilize a novel four core genotype mouse model to differentiate the...

Federal Grant Award Summary Duke University's Office of Research Administration received a $170,753 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective May 14, 2025, with a completion date of November 30, 2026. This award funds biomedical research designed to elucidate the molecular mechanisms by which Chlamydia trachomatis (CT), the most common sexually transmitted...

This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $458,050.00 to Marquette University to conduct research on the temperature-sensitive structures and processes that underlie fertility in nematode species. The key objectives of this 3-year project are to: 1) Determine how the stability of the synaptonemal complex, a critical meiotic structure, contributes to the...

This three-year $713,098 National Science Foundation project grant supports research at Colorado State University-Pueblo to quantify the effects of temperature on phagocytosis by immune cells in desert tortoises. The NSF Division of Integrative Organismal Systems awarded the grant under the Biological Sciences program (CFDA 47.074), which aims to advance biological knowledge and enhance understanding of major problems. The university will study how varying temperatures impact the ability of...

Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Virginia a Project Grant of $450,766 under the Allergy and Infectious Diseases Research program (CFDA 93.855) for research on inter-organelle communication mechanisms during Chlamydia infection. Awarded on August 8, 2025, with completion targeted for July 31, 2027, this project will deliver fundamental research findings addressing how Chlamydia trachomatis—the leading cause...

This Project Grant, awarded by the National Science Foundation's Division of Integrative Organismal Systems under the Biological Sciences program (CFDA 47.074), provides $423,262 in funding to the University of Wyoming for a three-year research initiative (August 1, 2025–July 31, 2028). The project investigates the neural circuits and specific neuronal cell types that govern huddling behavior as a form of behavioral thermoregulation in laboratory mice. The research aims to identify and...

Federal Grant Award Summary Oklahoma State University received a $145,745 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective August 1, 2025, through July 31, 2027. The award supports research to elucidate the mechanisms by which Chlamydia trachomatis modulates host inflammasome activation, addressing a critical knowledge gap in understanding chlamydial pathogenesis. The...

Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The University of Kentucky Research Foundation a Project Grant totaling $423,500 under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective July 1, 2025, through June 30, 2027. This research project investigates the functional roles of chlamydial polymorphic membrane proteins (PMPs), specifically PMPI, during the infectious cycle of Chlamydia trachomatis. The...