Project Grant R15AG104800
Award Date 8/15/26
Completion Date 7/31/29
Dollars Obligated $540K
Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
Westchester, CA 90045, USA
Similar Awards
- The National Institute on Aging awarded The Trustees of Columbia University in the City of New York $690,865 on January 15, 2026, under the Aging Research program (CFDA 93.866) to investigate the relationship between mitochondrial oxidative phosphorylation capacity and resilience in human aging. The research leverages two unique human datasets: the MISBIE Study, which includes patients with and without genetically determined severe mitochondrial disease, and the Baltimore Longitudinal Study of...
- The National Institute on Aging awarded the University of Rhode Island $567,224 on February 1, 2026, under the Aging Research program (CFDA 93.866) to investigate tissue-specific regulation of mitochondrial DNA (mtDNA) mutations across aging and lifestyle interventions. The research examines how different tissues accumulate and clear mtDNA mutations, the effects of exercise and caloric restriction on mtDNA heteroplasmy, and the mechanisms underlying mitochondrial dysfunction in aging and...
- The National Institute on Aging awarded The Leland Stanford Junior University $658,147 for Project Grant R01AG096626 on September 1, 2026, under the Aging Research program (CFDA 93.866). The award funds research into mechanisms of skeletal muscle maintenance relevant to Alzheimer's disease and Alzheimer's disease-related dementia. The research examines how mitochondrial dysfunction, particularly reverse electron transport along mitochondrial complex I, contributes to NAD+ depletion during aging....
- The National Institute on Aging awarded New York University $466,125 under the Aging Research program (CFDA 93.866) on January 15, 2026, to develop innovative magnetic resonance imaging analysis tools for identifying microstructural biomarkers of skeletal muscle health across the lifespan. The project, titled "(Micro)structural Biomarkers of Skeletal Muscle Health Across the Lifespan," addresses sarcopenia—a leading cause of disability and mortality in aging populations—by creating...
- The National Institute on Aging awarded Boston University (Trustees of Boston University, doing business as Boston University Medical Campus) $1.531778 million on September 15, 2025, under the Aging Research program (CFDA 93.866, Assistance Listing) to conduct research on tRNA modifications regulating mitochondrial function and the mitochondrial proteome in Alzheimer's disease and related dementias. The project runs through June 30, 2030, with place of performance at Roxbury, Massachusetts....
- The National Institute on Aging awarded the University of California, San Diego $440,000 on August 15, 2026, for Project Grant R21AG104288 under the Aging Research program (CFDA 93.866). The award funds research defining the role of ATG9B protein in cardiac aging and mitochondrial dysfunction in cardiomyocytes. The work investigates how ATG9B regulates mitochondrial morphology and quality control in aging hearts, with preliminary findings showing that ATG9B levels decline in aging mouse hearts...
- The National Institute on Aging awarded the University of Wisconsin System $698,690 on February 1, 2026, under the Aging Research program (CFDA 93.866) to conduct research on the molecular mechanisms of fiber type-specific skeletal muscle dysfunction with aging. The research quantifies proteome changes associated with fiber type-specific atrophy in older males and females, determines cross-bridge mechanisms for fiber type-specific impairments in contractile function, and identifies fiber...
- The National Institute on Aging awarded Vanderbilt University $482,800 on February 1, 2026, under the Aging Research program (CFDA 93.866) to conduct research on sphingolipid-dependent remodeling of mitochondria in aging cells through the project grant R01AG092718. The project investigates how accumulation of sphingolipids contributes to mitochondrial dysfunction during aging and tests whether targeting lipid transfer activities at inter-organelle junctions could promote longevity and...
- The National Institute on Aging awarded the University of Pittsburgh $664,619 on January 1, 2026, under the Aging Research program (CFDA 93.866) to develop multiscale computational and experimental models of neurometabolic coupling across age-related cognitive decline and late-onset Alzheimer's disease. The research integrates in vivo two-photon microscopy, multispectral wide-field imaging, and magnetic resonance imaging to characterize the relationship between neuronal activity and metabolic...
- The National Institute on Aging awarded Dana-Farber Cancer Institute, Inc. $1,526,573 on July 15, 2026, under the Aging Research program (CFDA 93.866) to conduct research on rejuvenation of aged hematopoietic stem cells and bone marrow niche function via mitochondrial engineering. The research addresses how aging impairs hematopoietic stem cell (HSC) transplantation success by driving mitochondrial dysfunction in donor cells. The work investigates mitochondrial transfer between HSCs and...