Project Grant R15AG101767
- The National Institute on Aging awarded the University of California, Los Angeles $623,176 on September 1, 2026, under the Aging Research program (CFDA 93.866) to conduct research on modifiable risk factors for Alzheimer's disease and related dementias among individuals aged 90 and older. The research triangulates evidence across four data sources—the LifeAfter90 Study (1,397 participants, all aged 90), the 90+ Study (1,630 participants, all aged 90), the Health and Retirement Study (3,359...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded the University of California, Los Angeles $146,750 under the Aging Research program (CFDA 93.866) on July 1, 2026, to identify molecular-neuropathological signatures in Alzheimer's disease, frontotemporal lobar degeneration, and long COVID. The recipient will employ single-cell spatial multi-omics on postmortem brain tissues to characterize molecular and cellular alterations linked to selective...
- The National Institute on Aging awarded the University of California, Berkeley $549,260 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop advanced large language model-based AI tools that enhance precision in predicting Alzheimer's disease pathology and cognitive outcomes. The research addresses critical gaps in precision medicine for Alzheimer's disease, particularly the need to capture patient heterogeneity, accurately identify treatment candidates for...
- The National Institute on Aging awarded The Regents of the University of Colorado, doing business as University of Colorado-Denver, $189,963 on July 1, 2026, under the Aging Research program (CFDA 93.866) to support research led by Dr. Carlisle investigating the contributions of biological sex and sex hormones to cognitive reserve across the cognitive spectrum of Alzheimer's disease. The research will assess how estrogen and sex differences affect Alzheimer's disease risk, with particular...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $170,668 to the University of California, San Diego on October 24, 2025, under the Aging Research program (CFDA 93.866) to support research into s-nitrosylated phospholipase D3 in Alzheimer's disease pathophysiology. The funded research investigates the mechanistic role of s-nitrosylated phospholipase D3 (SNO-PLD3) in Alzheimer's disease. The work builds on prior mass spectrometry findings that...
- The National Institute on Aging awarded The Regents of the University of California, San Francisco $902,000 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the steroid hormone androst-5-ene-3β,17β-diol (ADIOL) as a regulator of cognitive resilience and protection against age-related cognitive decline and Alzheimer's disease. The project conducts mechanistic studies in mice and correlative studies in humans to test the hypothesis that ADIOL, acting through...
- The National Institute on Aging awarded the University of Southern California $149,190 on August 6, 2026, under the Aging Research program (CFDA 93.866) to investigate how early-stage Alzheimer's disease disrupts coordinated release dynamics between acetylcholine and norepinephrine in the cortex and how this discoordination impairs cognitive performance. The research characterizes the evolution of coordinated cortical acetylcholine and norepinephrine release activity in vivo in wildtype mice,...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded The Regents of the University of California, San Francisco $194,573 on February 20, 2026, under the Aging Research program (CFDA 93.866) to investigate mechanisms of microglial-mediated sex-based differences in tauopathy. The recipient will conduct basic research examining how gonadal hormones contribute to sex-based differences in tau-related neurodegeneration through their effects on microglia, the...
- The National Institute on Aging awarded the University of California, Santa Barbara $200,918 on March 18, 2026, under the Aging Research program (CFDA 93.866) to conduct research establishing the role of ovarian hormones in spatial navigation as an early diagnostic target for Alzheimer's disease. The research investigates associations between ovarian hormones and navigation ability in women across two critical timeframes: menstrual cycle phase-level fluctuations and longer-term endocrine aging...
- The National Institute on Aging awarded The Leland Stanford Junior University $125,766 on July 1, 2026, under the Aging Research program (CFDA 93.866) to identify molecular mediators linking cardiometabolic risk factors to Alzheimer's disease. The research identifies plasma protein and metabolite mediators of cardiometabolic pathways that contribute to Alzheimer's disease risk using large-scale omics data from the UK Biobank and Million Veteran Program. The project comprises three specific aims:...
The National Institute on Aging awarded CAL Poly Humboldt Sponsored Programs Foundation $267,525 on September 5, 2026, under the Aging Research program (CFDA 93.866) to conduct systems biology research investigating the role of klotho and estrogen in combating neurodegeneration associated with Alzheimer's disease. The project applies ordinary differential equations and agent-based modeling to simulate molecular signaling cascades, cellular metabolic reprogramming, and spatial microenvironment dynamics in the hippocampus. Three specific aims guide the research: extending an ODE model of NF-κB signaling to incorporate estrogen and klotho and elucidate their regulatory roles in inflammation; developing a multiscale ODE model to explore how apolipoprotein E4 (APOE4) and estrogen co-regulate microglial dysfunction and blood-brain barrier breakdown; and integrating these insights into a spatially explicit agent-based model of the hippocampus to capture how estrogen and klotho modulate immune-cell behavior and barrier permeability over time. The work addresses sex-specific vulnerability to Alzheimer's disease, particularly in the presence of the APOE4 genotype, by investigating the interplay between hormonal decline, immune dysregulation, and metabolic dysfunction. Work is performed in Arcata, California. The period of performance runs from September 5, 2026 to August 31, 2029. The assistance type is a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $267.5k | 9/3/26 |