Project Grant R15AG083621
- Federal Grant Award Summary Boston University Medical Campus received a $686,700 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded August 15, 2025, with completion by July 31, 2027. This grant supports a two-phase research initiative investigating chronic wound stress as a catalyst for systemic aging and functional decline. The project will establish and validate a mouse model simulating chronic wound stress across different adult...
- Federal Project Grant Award Summary The University of Massachusetts Medical School received a $626,409 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) for the period February 1, 2026, through January 31, 2031. The award funds research investigating how aging impairs wound healing through hematopoietic stem cell (HSC) mechanisms. The research will utilize single-cell epigenomics technologies to characterize how aging affects gene...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Northeast Ohio Medical University a $611,680 Project Grant on February 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the molecular mechanisms of vascular aging in metabolic syndrome. The research focuses on O-GlcNAcylation, a posttranslational protein modification mediated by O-GlcNAc transferase (OGT), and its role in vascular smooth muscle cell (VSMC) de-differentiation and dysfunction....
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Washington University a Project Grant totaling $556,121.00 under the Aging Research program (CFDA 93.866) effective January 15, 2026, with a completion date of December 31, 2030. This research project investigates transgenerational epigenetic adaptation of longevity changes in response to repeated environmental stresses. The primary deliverable is scientific research examining how repeated successive generational...
- Federal Grant Award Summary The National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), awarded the University of Pennsylvania a $2.8 million Project Grant effective February 1, 2026, through January 31, 2031, to conduct research on the epigenetics of aging and age-associated diseases. The research program focuses on two primary mechanisms: chromostasis (homeostatic mechanisms that maintain dynamic chromatin integrity) and regulation of the senescence-associated...
- Federal Project Grant Award Summary Cleveland Clinic Lerner College of Medicine of Case Western Reserve University received a $659,309 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) awarded on December 15, 2025, with an ultimate completion date of November 30, 2030. This five-year research initiative will investigate the molecular mechanisms underlying sex-dependent differences in endothelial cell (EC) function, specifically focusing on...
- Federal Grant Award Summary The National Institute on Aging awarded a $1,588,818 Project Grant to Cleveland Clinic Lerner College of Medicine of Case Western Reserve University (operating as Cleveland Clinic Lou Ruvo Center) for the period June 1, 2025, through February 28, 2030, under the Aging Research program (CFDA 93.866). The award funds development of a Multimodal, Multiscale and Multistage Systems Biology (M3SB) infrastructure designed to advance precision medicine in Alzheimer's...
- Federal Grant Award Summary The National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), awarded The Washington University a Project Grant of $2,631,670 effective September 1, 2025, through August 31, 2029. This research initiative investigates age-related deficits in episodic memory for both the content and structure of naturalistic events, with particular focus on understanding memory loss mechanisms in aging and Alzheimer's disease (AD). The project will deliver...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded The Washington University $128,373.00 under the Aging Research program (CFDA 93.866) on August 15, 2025, with a completion date of May 31, 2030. This K01 career development research project will conduct a rigorous comparative analysis of state-of-the-art biological age clocks across epigenetic, proteomic, and neuroimaging modalities using longitudinal human Alzheimer's disease (AD) datasets. The research will...
- Federal Grant Award Summary The National Institute on Aging awarded Columbia University's Health Sciences Division a $852,273 Project Grant (CFDA 93.866, Aging Research program) effective September 1, 2025, through May 31, 2030, to conduct genetic mapping research on RNA modifications in the aging human brain and their relationship to Alzheimer's disease (AD). The primary deliverables include the creation of a comprehensive atlas of N6-methyladenosine (M6A) and pseudouridine modifications across...
The National Institute on Aging (NIA) awarded The College of Wooster a $482,620 Project Grant under the Aging Research program (CFDA 93.866) on April 15, 2026, with a completion date of March 31, 2029. This award supports the development and experimental validation of computational regulatory network models that predict how aging disrupts epithelial wound healing and angiogenesis. The primary deliverable is a suite of single-cell network models that reproduce age-dependent cellular transitions—specifically the commitment of epithelial cells to senescence, hybrid epithelial-to-mesenchymal transition (E/M), or mesenchymal states in response to environmental cues. These models will integrate detailed molecular regulatory networks with multi-scale cellular behaviors to transform qualitative understanding of aging mechanisms into predictive tools for identifying new therapeutic interventions. The project will produce quantitative computational tools addressing a critical gap in aging research by establishing causative mechanisms linking aging microenvironments to impaired wound healing. Specific research objectives include developing models that reproduce mutually exclusive commitment pathways between senescence and mesenchymal states in age-dependent epithelial healing, and characterizing how aging disrupts angiogenic patterning during tissue repair. The grant supports research conducted at the College of Wooster's facility in Wooster, Ohio, leveraging the institution's capabilities in complex scientific research with emphasis on computational modeling and experimental validation methodologies.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $482.6k | 4/21/26 |