Project Grant R13AR065834

This Cooperative Agreement award of $1,225,804, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support a Phase 1 clinical trial to assess the safety and preliminary efficacy of bilateral cerebellar deep brain stimulation (DBS) in individuals with spinocerebellar ataxia (SCA) types 1 and 3. The study aims to understand the physiology of the deep...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853), provides $776,503 to The General Hospital Corporation (Massachusetts General Hospital) to investigate the role of perivascular inflammation and vascular remodeling in cerebral small vessel diseases (CSVD), which can lead to intracerebral hemorrhage. The project will leverage autopsy cases and mouse...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $605,523 to The Trustees of Columbia University in the City of New York, Health Sciences Division, to conduct research on developing therapies that target Purkinje cell synaptic changes to restore circuit function in cerebellar degeneration. The research aims to determine if...

This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $227,205 to Cedars-Sinai Medical Center to conduct research aimed at identifying pathological signatures and molecular markers in the motor cortex of patients with amyotrophic lateral sclerosis (ALS). The key research objectives are to: 1) use advanced MRI techniques to...

This Project Grant award of $390,178 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will fund research to identify molecular, cellular, and electrical biomarkers for diagnosing Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). The key product will be a matrix of biomarkers derived from investigating gene expression, functional pathways, and...

This $438,365 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to investigate the role of the CD38 protein and its potential as a therapeutic target for Spinal and Bulbar Muscular Atrophy (SBMA). The research aims to use stem cell technology and CRISPR-corrected isogenic controls to examine metabolic alterations in SBMA patient-derived...

The U.S. Department of Health and Human Services, National Institute of Neurological Disorders and Stroke (NINDS) awarded a $429,000 Project Grant to Thomas Jefferson University, doing business as Sidney Kimmel Medical College, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The funding supports research to develop a mechanistic understanding of Spinal and Bulbar Muscular Atrophy (SBMA) pathogenesis and explore therapeutic approaches....

The U.S. National Institute of Neurological Disorders and Stroke (NINDS) awarded a $1,643,228 Cooperative Agreement grant under the Drug Abuse and Addiction Research Programs (CFDA 93.279) to Worcester Polytechnic Institute (WPI) to develop an Integrative Mindfulness-Based Predictive Approach for Chronic Low Back Pain Treatment (IMPACT). The key objectives of this 2-year IMPACT project are to: 1) Initiate a clinical trial of Mindfulness-Based Stress Reduction (MBSR) for chronic low back pain...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under CFDA program 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders, provides $621,073 to Vanderbilt University Medical Center (VUMC) to investigate cerebrospinal fluid (CSF) dynamics in Huntington's disease (HD). The overarching objective is to apply innovative neuroimaging methods to characterize changes in CSF production, transport, and resorption across stages...

The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $147,486 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the Massachusetts Institute of Technology (MIT) from July 1, 2025 to June 30, 2027. The grant funds the development of a novel Magnetic Resonance Imaging (MRI) method to concurrently measure brain tissue displacement, blood dynamics, and cerebrospinal fluid (CSF) flow in humans. This research...