Project Grant R03TW007982

This $811,396 Project Grant, awarded by the National Institute of Allergy and Infectious Diseases under CFDA 93.855 Allergy and Infectious Diseases Research, is focused on understanding the mechanisms of lipid/metabolite and drug transport in Mycobacterium tuberculosis and related mycobacteria. The major objectives are to establish the molecular mechanisms and structures of three specific MMPL transporter proteins and their complexes with interacting partner proteins. Key activities include...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) is intended to support the development and validation of a chemically induced dimerization (CID) system capable of detecting nanomolar concentrations of coenzyme A (CoA) in the presence of excess acetyl-CoA. This CID system is being created to provide a universal assay method for screening histone acetyltransferases, which are important...

This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will support research to characterize metabolic profiles and outcomes among tuberculosis (TB) patients in Tanzania. The $201,549 award to the Medical University of South Carolina will fund a 5-year study with the following objectives: Measure and describe metabolic markers and TB severity at the time of TB diagnosis, testing...

This $450,500 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to the University of Arkansas for Medical Sciences (UAMS) aims to enhance the understanding of macrophage subsets in tuberculosis (TB) infection and lesion biology. The project will leverage the C3HeB/FeJ mouse model, which forms the caseous necrotic lesions observed in human TB, to investigate how different lung macrophage subsets influence...

The federal Project Grant award of $746,602 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Cornell University. The objective of this 5-year project is to examine how compounds that stimulate cyclic AMP (cAMP) production in the tuberculosis (TB) bacterium Mycobacterium tuberculosis (MTB) can inhibit its growth and metabolism, potentially enhancing the efficacy of existing TB treatments...

The National Institute of Allergy and Infectious Diseases (NIAID) awarded a 5-year, $1,640,492 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Albert Einstein College of Medicine to study the role of the ESX5 secretome of Mycobacterium tuberculosis in TB and TB-HIV pathogenesis and immunity. The researchers generated a genetic deletion of the ESX5 locus, which they found produced a live attenuated vaccine that is highly effective at preventing TB in...

This Project Grant, awarded by the National Institute of Allergy and Infectious Diseases (NIAID, CFDA 93.855 Allergy and Infectious Diseases Research), provides $466,500.00 in funding to the University of North Carolina at Chapel Hill (UNC-CH) to conduct research on the bacterial genetic basis underlying the transmissibility of tuberculosis (TB). The project aims to: (1) identify key mutations that drive high transmissibility in Mycobacterium tuberculosis (MTB) using a global collection of...

This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $813,450 to Case Western Reserve University to conduct research evaluating human T cells specific for Mycobacterium tuberculosis (MTB) antigens that are processed and presented by infected macrophages. The objective is to gain insight into which MTB antigens are presented and the composition and kinetics of the T cell repertoire targeting these...

This three-year Project Grant from the National Science Foundation's Division of Molecular and Cellular Biosciences totals $1,512,792 to fund research at Louisiana State University examining the gene regulatory networks affected by purine catabolites in bacterial pathogens. The research aims to identify additional transcription factors in Burkholderia thailandensis responsive to urate and xanthine, which accumulate in host tissues during infection due to production of reactive oxygen species....

This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), Catalog of Federal Domestic Assistance (CFDA) 93.855 Allergy and Infectious Diseases Research program, aims to inform the development of a simple, highly sensitive and specific, non-sputum-based point-of-care test (POCT) for tuberculosis (TB) diagnosis. The $850,711 award to Albert Einstein College of Medicine, located in Bronx, NY, will support the investigation of a panel of six monoclonal...