This National Institute of Mental Health (NIMH) Project Grant award under the Mental Health Research Grants program (CFDA 93.242) provides $1,677,954 to The Trustees of Columbia University in the City of New York to conduct translational research studies in humans and mice. The project aims to elucidate the circuit-level neurobiological mechanisms underlying auditory hallucinations, a core symptom of psychosis for which treatments are often ineffective. The research combines computational...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $231,547 to George Mason University to research the role of NMDA receptor signaling in regulating hippocampal network dynamics and spatial memory. The project aims to better understand the neurobiological mechanisms underlying cognitive deficits in schizophrenia, with a focus on the potential regulatory function of GluN2B-type...
The National Institute of Mental Health (NIMH) awarded a $908,174 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the Lieber Institute for Brain Development to conduct research entitled "Understanding Schizophrenia Risk Mechanisms via Multimodal Analysis of Patient-Derived Neurons and 3D Cortical Organoids and Correlation with Clinical and Cognitive Phenotypes." The project aims to utilize induced pluripotent stem cell (iPSC) technology and 3D cortical organoids to...
This $414,650 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research to understand the mechanisms regulating the maturation of "silent synapses" and their impact on the refinement of excitatory neural networks during critical developmental periods. The research, led by the University of Pittsburgh, aims to identify key signaling pathways controlling the pace of silent synapse maturation...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), is providing $731,035 to St. Jude Children's Research Hospital Inc. to conduct research on the neurological mechanisms underlying psychotic symptoms in 22q11.2 Deletion Syndrome, a genetic disorder that significantly increases the risk of schizophrenia.
The key objectives of the research are to: 1) Determine if mimicking the neurological abnormalities...
The National Institute of Mental Health (NIMH) awarded a $234,000 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the University of Colorado-Denver to conduct research on how inhibitory synapses in the brain regulate the formation and function of excitatory synapses throughout development. The project aims to elucidate the cellular and synaptic mechanisms underlying the crosstalk between inhibitory and excitatory synapses, which is critical for maintaining the proper...
The National Institute of Mental Health (NIMH) awarded a 5-year, $706,404 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Thomas Jefferson University to study the pathophysiological roles of protein-protein interactions at excitatory synapses and their modifications in schizophrenia.
The key objectives are to examine how two specific protein-protein interactions altered in schizophrenia impact nanoscale molecular events to cause NMDA receptor hypofunction, and...
The National Institute of Mental Health (NIMH) awarded a $185,165 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Colorado State University, through its Sponsored Programs division, to conduct research on how the microRNA miR-137 affects both metabolic and neuronal function. This research aims to further understand how miR-137, which is strongly linked to schizophrenia and bipolar disorder, contributes to the metabolic dysfunction observed in these...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will fund a $464,750 investigation into the role of tandem repeat variation in the genetic risk of schizophrenia. The goal is to apply innovative algorithms for high-throughput tandem repeat genotyping to large, well-powered schizophrenia cohorts with whole genome sequencing data. This systematic study has the potential to uncover novel genetic risk...
This federal Project Grant award, valued at $647,833 and provided by the National Institute of Mental Health (NIMH), is funding research to investigate the role of the NKCC1-KCC2 chloride transporter system in cognitive impairment and social interaction deficits associated with psychiatric disorders such as schizophrenia.
The research, conducted by Northwestern University, aims to determine if depolarizing GABA signaling in the medial prefrontal cortex represents a convergent pathogenic...