Project Grant R03HL185270
- The National Heart, Lung, and Blood Institute awarded Duke University $238,516 on August 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct admixture mapping of genetic modifiers in sickle cell disease. The research leverages the National Heart, Lung, and Blood Institute's TOPMed program, which includes multiple cross-sectional adult sickle cell disease cohorts totaling more than 4,000 participants with whole genome sequencing data and extensive clinical...
- The National Heart, Lung, and Blood Institute awarded Vanderbilt University Medical Center $232,836 on December 1, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop biomarkers of ischemic risk in adults with sickle cell disease using non-invasive quantitative neuroimaging methods. The research uses arterial spin labeling MRI and other quantitative imaging techniques to test hypotheses regarding cerebral oxygen utilization in patients with sickle cell disease...
- The National Heart, Lung, and Blood Institute awarded Vanderbilt University Medical Center $873,449 on August 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to evaluate modern pharmacotherapy treatment regimens and prophylaxis for reducing infections in sickle cell disease. The recipient will conduct a population-based retrospective cohort study leveraging the Sickle Cell Data Collection Network (2010–2024) to assess children with sickle cell disease in Georgia,...
- The National Heart, Lung, and Blood Institute awarded the University of Illinois $1.497 million on September 15, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the pathophysiology of sickle cell-related kidney disease using sodium-glucose cotransporter-2 inhibitors (SGLT2I). The award funds research to evaluate whether the SGLT2I empagliflozin ameliorates kidney dysfunction in patients and animal models with sickle cell disease. Specific Aim #1 will utilize...
- The National Heart, Lung, and Blood Institute awarded $1.834 million to St. Jude Children's Research Hospital Inc. on July 5, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to test senescence-targeting therapies for improving hematopoietic stem cell function and mobilization in sickle cell disease. The research addresses pathologic bone marrow stress in sickle cell disease patients, which damages and depletes hematopoietic stem and progenitor cells and selects for...
- The National Heart, Lung, and Blood Institute awarded Emory University $797,648 on June 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate red blood cell-bound cell-free DNA as a predictor of acute anemia in sickle cell disease. The research examines whether elevated levels of cell-free DNA released during vaso-occlusive complications in sickle cell disease bind to toll-like receptor 9 (TLR9) on red blood cells, thereby modulating red blood cell clearance...
- The National Heart, Lung, and Blood Institute awarded Rutgers The State University of New Jersey, School of Nursing, $117,750 on May 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct proteomic profiling and neurocognitive assessment to uncover stroke mechanisms in adults with sickle cell disease. The study quantifies neurodegeneration-associated and mitochondrial proteins in a cohort of 90 sex- and age-matched adults comprising 30 healthy controls, 30...
- The National Heart Lung and Blood Institute awarded $1.449 million to the University of North Carolina at Chapel Hill on September 15, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837, R01HL177199) to conduct a multi-site prospective study examining the prevalence, clinical impact, and treatment response of sleep-associated hypoxemia in adults with sickle cell anemia. The study enrolls adult patients with homozygous sickle cell anemia (SCA) at four institutions—University of...
- The National Heart, Lung, and Blood Institute awarded the University of North Carolina at Chapel Hill $171,488 on September 30, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct a nationwide examination of access to comprehensive care in sickle cell disease. The research uses national Medicaid insurance claims data to address two analytic aims. The first aim identifies three groups of people with sickle cell disease—those who do not receive care from a...
- The National Heart, Lung, and Blood Institute awarded Emory University $1,288,327 on September 15, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct research on red blood cell survival in recipients with sickle cell disease. The research evaluates the impact of donor and recipient factors on transfused red blood cell (RBC) survival in sickle cell disease patients and examines mechanisms contributing to RBC clearance. The study proposes an experimental,...
The National Heart, Lung, and Blood Institute awarded the University of Tennessee Health Science Center $253,395 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to identify genetic modifiers of acute kidney injury in sickle cell disease. The award funds research evaluating candidate genetic variants—apolipoprotein L1 (APOL1), hemeoxygenase-1 (HMOX1), BCL11A, and alpha thalassemia—for their association with acute kidney injury (AKI) in a well-genotyped and phenotyped cohort of children and adults with sickle cell disease. The project will develop a machine learning model integrating genetic variables and clinical electronic health record data to predict AKI risk during hospitalization, with the long-term goal of enabling incorporation of AKI prediction into the electronic medical record to institute protective measures. The period of performance runs from September 1, 2026, through May 31, 2028. Work is performed in Memphis, Tennessee. The research addresses how genetic modifiers contribute to chronic kidney disease development in sickle cell disease, an independent risk factor for increased morbidity and earlier mortality in this patient population.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $253.4k | 8/24/26 |