Identifying inflammatory and endothelial mechanisms promoting cardiac deformation in women with a history of preeclampsia
Active Project Grant Awarded Last action
- Award ID
- R03HL177034
- Recipient
-
The Christ Hospital UEI EK4SMPJKY5E4
- Awarding agency
-
National Heart Lung and Blood Institute
National Institutes of Health, Department of Health and Human Services
- Obligated
- $297,450
Award facts
- Assistance listing
- 93.837 Cardiovascular Diseases Research
- Completion date 94% complete
- Place of performance
- Cincinnati, OH 45219, USA
Award details come from USAspending.gov.
Description
- Abstract
- Women with a history of preeclampsia (pree) are at a 2-fold higher risk of cardiovascular disease and develop subclinical cardiovascular disease 5 years earlier than women with normotensive pregnancies; however, the mechanism remains unknown. In our K23 study of 150 participants including 90 with history of preeclampsia and 60 with normotensive pregnancy 2-10 years postpartum, we found evidence of subclinical cardiovascular disease (myocardial deformation and vascular dysfunction) in those with history of pree. Our central hypothesis is that women with a history of preeclampsia will demonstrate long-term elevations in biomarkers of inflammation and endothelial dysfunction and that these will be directly associated with the observed subclinical cardiovascular disease. Utilizing the K23 biorepository of 150 samples, we will measure levels of inflammatory cytokines, endothelial biomarkers and endothelial microvesicles. We will then examine the relationship of these biomarkers to measurements of myocardial deformation (cmri) and vascular functional (endopat and sphygmocor). Upon completion of these aims, we expect to establish endothelial dysfunction and chronic inflammation as the mechanisms responsible for the myocardial deformation and vascular dysfunction in women with history of preeclampsia 2-10 years postpartum. These insights will significantly advance our understanding of these mechanisms and guide future pharmacological interventions.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $99,150 | |
| Amendment | $99,150 | |
| Original award | $99,150 |
Quick answers
Who received award R03HL177034?
R03HL177034 was awarded to The Christ Hospital by National Heart Lung and Blood Institute (National Institutes of Health) on January 1, 2025.
How much is award R03HL177034 worth?
$297,450 has been obligated on R03HL177034.
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