Project Grant R03DK147068
- Federal Grant Award Summary Award Overview: The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded Indiana University Indianapolis $811,217 under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) on February 18, 2026, with an ultimate completion date of January 31, 2031. This Project Grant supports fundamental research on signaling mechanisms of ultra-stable single-chain insulin (SCI) analogs and the development of...
- Federal Grant Award Summary Indiana University Indianapolis received a $813,999 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective May 1, 2026 through February 28, 2031. This five-year research project develops and tests stem cell-impregnated thread-reinforced encapsulation devices (THREDs) for surgical treatment of acute and chronic...
- Federal Project Grant Award Summary Indiana University Indianapolis received a $480,697 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective March 1, 2026 through February 28, 2031. The award funds basic biomedical research focused on understanding the mechanisms of hepatic fibrosis associated with metabolic dysfunction-associated...
- Federal Grant Award Summary The Beckman Research Institute of the City of Hope received a $178,000 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective May 1, 2026 through April 30, 2028. This award funds research investigating how the native pancreatic microenvironment regulates human islet cell function in both healthy individuals and those...
- Federal Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded Scripps Research Institute a $801,662 Project Grant effective August 15, 2025, through June 30, 2029, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The research project investigates the initiation of anti-islet autoimmunity in Type 1 Diabetes (T1D), a CD4 T cell-mediated autoimmune disease, with particular focus on understanding the role...
- Federal Project Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded $1,264,088 to the Beckman Research Institute of the City of Hope on July 21, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to support research on epigenetic regulation of genomic stability in beta-cell homeostasis through April 30, 2030. The project seeks to elucidate mechanisms protecting beta cells from DNA damage during...
- Federal Grant Award Summary The University of Florida received a $754,682 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective May 1, 2026, through April 30, 2030. This research grant supports a comprehensive investigation into beta cell impairment mechanisms in Type 1 Diabetes (T1D) by examining glucose metabolism dysfunction from both...
- Federal Grant Award Summary The Beckman Research Institute of the City of Hope was awarded $1,453,844 on August 20, 2025, through the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct research on chromatin remodeling factors and mechanisms in diabetic microvascular complications. This Project Grant, which extends through June 30, 2030, will deliver foundational research addressing...
- Federal Grant Award Summary Indiana University Indianapolis received a $234,287 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded September 15, 2025, with completion targeted for August 31, 2027. This award funds research to investigate the social and environmental determinants of vitamin D deficiency in pediatric chronic kidney disease (CKD)...
- Federal Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $237,750 Project Grant to the Trustees of Indiana University (Indiana University Indianapolis) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) for the period September 15, 2025 through August 31, 2027. The award supports a rigorous qualitative research study examining nephrology practices' participation decisions and care model reforms...
Indiana University Indianapolis received a $149,738 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective July 1, 2026, through June 30, 2028. The award funds biomedical research aimed at unraveling the transcriptional mechanisms by which ZBED family proteins regulate pancreatic beta cell survival, function, and immune tolerance during autoimmune type 1 diabetes (T1D). The research leverages in vivo CRISPR/Cas9 screening, human islet single-cell RNA sequencing analysis, and chromatin immunoprecipitation sequencing to identify opposing regulatory effects of ZBED2 and ZBED3 transcription factors on beta cell fate and stress response. The funded research will deliver two primary products: (1) characterization of ZBED3's role in regulating beta cell immunogenicity, functional maturation, and stress adaptation through studies using genetically engineered beta cells derived from human induced pluripotent stem cells (iPSCs) and primary islets; and (2) investigation of ZBED2-induced immune tolerance mechanisms and its antagonistic effects relative to ZBED3. The project is designed to advance understanding of beta cell vulnerability mechanisms and inform therapeutic strategies for enhancing beta cell resilience in diabetes replacement and immunomodulatory approaches.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $149.7k | 6/19/26 |