Project Grant R03DK145931
- Federal Grant Award Summary Versiti Blood Health, Inc. received a $242,048 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective September 8, 2025 through August 31, 2027. The award funds research investigating DNA damage responses and genotoxicities resulting from genome editing in hematopoietic stem and progenitor cells (HSPCs), with particular...
- Federal Grant Award Summary Boston Children's Hospital received a $801,000 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective September 15, 2025, with completion targeted for July 31, 2030. The research initiative investigates stress granule formation and function in erythroid (red blood cell) development, focusing on the molecular mechanisms that...
- Federal Grant Award Summary Fred Hutchinson Cancer Center received a $680,321 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded on May 15, 2025, with a completion date of February 28, 2029. The grant supports basic science research investigating the molecular mechanisms by which Delta-Like Homologue 1 (DLK1), a non-canonical Notch ligand, regulates hematopoietic stem cell (HSC) quiescence. The...
- Federal Grant Award Summary Vitalant Research Institute received a $262,500 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 15, 2025, with completion targeted for August 31, 2027. The research initiative investigates the genetic and molecular drivers of mitochondrial DNA (mtDNA) levels in blood components and their potential role in transfusion-related acute lung injury. The...
- Federal Project Grant Award Summary Boston Children's Hospital received a $469,042 project grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective September 1, 2025, through August 31, 2027. The grant funds the transformation and optimization of a human induced pluripotent stem cell (iPSC)-derived bone marrow organoid to advance hematopoiesis research. The...
- Federal Project Grant Award Summary Albert Einstein College of Medicine received a $271,562 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective July 9, 2025, with a completion date of March 31, 2028. The research project investigates the interplay between DDX41 (Dead-Box Helicase 41) and CUX1 (Cut-Like Homeobox 1) mutations in hematopoiesis to elucidate mechanisms underlying myelodysplastic...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded $445,000 to The Children's Hospital of Philadelphia Research Institute under the Cardiovascular Diseases Research program (CFDA 93.837) on July 15, 2025, for a three-year project extending through June 30, 2028. This Project Grant funds research to determine the genetic mechanisms driving hematopoietic stem and progenitor cell (HSPC) production in vitro. The research focuses on the tropomyosin 1 gene's role...
- Federal Project Grant Summary Fred Hutchinson Cancer Center received a $776,511 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 1, 2025 through May 31, 2029. The award funds research to develop and validate a three-dimensional engineered hemogenic vascular niche model that replicates the microenvironmental conditions of the aortic vascular niche where hematopoietic stem cells (HSCs)...
- Summary Versiti Blood Health, Inc. received a $604,301 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 1, 2025, with a completion date of April 30, 2029. The award funds research investigating membrane-cytoskeleton interactions in megakaryocytes and platelets, with particular focus on understanding the molecular mechanisms underlying platelet production and function. The research...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded New York Blood Center, Inc. a Project Grant of $801,628 under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 1, 2025, through April 30, 2029. This award supports basic science research investigating the mechanisms by which erythroblastic island macrophages (EBI M) regulate normal erythropoiesis and contribute to pathological red blood cell overproduction in polycythemia...
Versiti Blood Health, Inc. received a $127,500 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) for the period February 5, 2026 through December 31, 2027. The award supports research investigating the role of force-directed lipid metabolism in the endothelial-to-hematopoietic transition (EHT), a developmental process critical to hematopoietic stem cell (HSC) production. The research utilizes the zebrafish Danio rerio model system to examine how mechanical forces from blood flow regulate the Yes-Associated Protein (YAP) transcription factor and its role in mediating the cellular reprogramming of hemogenic endothelial cells into self-renewing blood stem cells. The research deliverables include basic and translational science findings aimed at identifying previously undefined developmental signals necessary for efficient HSC production, which carries direct therapeutic implications for improving clinical protocols for stem cell expansion and de novo production. By elucidating the molecular mechanisms linking blood flow-induced mechanical forces to HSC specification and self-renewal capacity, this work addresses a critical gap in current in vitro protocols that have yet to efficiently produce long-lived multipotent HSCs suitable for clinical applications in treating hematologic malignancies such as leukemia and lymphoma.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.8k | 2/18/26 | ||
| Not listed | $123.8k | 2/5/26 |