Project Grant R03DE036186
- The National Institute of Allergy and Infectious Diseases awarded the Scripps Research Institute a Project Grant of $270,443 on June 23, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to characterize host-specific profiles of defective viral genomes of influenza virus. The research examines defective viral genomes (DVGs) that emerge during influenza virus replication and their role in modulating viral fitness, pathogenicity, and immune responses. The work...
- The National Institute of Allergy and Infectious Diseases, a component of the Department of Health and Human Services National Institutes of Health, awarded $120,312 to the University of California, Berkeley on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds research into adenosine deaminases acting on RNA (ADARs), enzymes that edit RNA to regulate gene expression and immune responses. The research aims to identify viral and host...
- The National Institute of Allergy and Infectious Diseases awarded Georgia State University Research Foundation Inc. $795,962 on August 4, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate how gut microbiota composition influences respiratory viral infection outcomes and alveolar macrophage function. The research examines the protective mechanisms by which segmented filamentous bacteria (SFB) colonization in the intestine confers resistance to severe...
- The National Institutes of Health Office of the Director awarded Yale University a cooperative agreement totaling two dollars on March 13, 2026, to develop new strategies to characterize the human virome by leveraging primary cell and organoid culture methods. The award supports research to address technological knowledge gaps in virome detection, specifically focusing on eukaryotic cell-infecting viruses, RNA viruses, and viruses within human tissues. The project concentrates on the human...
- The National Institute of Allergy and Infectious Diseases, part of the Department of Health and Human Services, awarded $444,125 to the University of Virginia on February 10, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to decode immune responses during sequential rhinovirus infections. The recipient will conduct a comprehensive analysis of immune cells and anti-viral mediators in blood and nasal specimens collected during sequential homotypic and heterotypic...
- The National Institute of Allergy and Infectious Diseases awarded the Regents of the University of California at Riverside $213,048 on April 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate how SARS-CoV-2's nucleocapsid (N) protein manipulates host-cell translation machinery to establish viral replication during early infection. The research identifies the molecular mechanisms by which N protein physically and functionally interacts with human...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded the Trustees of Boston University $245,250 on May 1, 2026, for research on non-canonical translation of pneumovirus messenger RNAs under the Allergy and Infectious Diseases Research program (CFDA 93.855). The research identifies viral and cellular factors that enable respiratory syncytial virus (RSV) and human metapneumovirus to translate their mRNAs through mechanisms independent of the standard translation initiation...
- The National Institute of Allergy and Infectious Diseases, a component of the Department of Health and Human Services National Institutes of Health, awarded $267,000 to The Children's Hospital Corporation (doing business as Boston Children's Hospital) on August 17, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds research decoding gasdermin D (GSDMD) pore clustering as a regulatory checkpoint controlling pyroptosis, a lytic and inflammatory form...
- The National Institute of Allergy and Infectious Diseases awarded The Regents of the University of California, San Francisco $666,065 on June 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the molecular basis for immunogenic B cell responses to virus-like antigen display. The research leverages a modular platform of liposomes decorated with model antigens to independently control epitope affinity and density. The work aims to identify proximal...
- The National Institute of Allergy and Infectious Diseases awarded the University of Virginia $773,388 on April 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to decode the cellular networks governing respiratory mucosal IgA immunity. The research addresses mechanisms driving robust respiratory mucosal immunity, particularly IgA responses following infection or vaccination, with the goal of informing next-generation mucosal vaccine strategies against...
The National Institutes of Health Office of the Director awarded J. David Gladstone Institutes $377,999 on September 1, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to define molecular interactions between commensal respiratory viruses and the human host. The research team will generate molecular clones of abundant commensal viruses in the respiratory tract and characterize viral infection and host responses in primary human airway organoids using single-cell RNA sequencing. The work will also map virus-host protein-protein interaction networks through affinity-purification mass spectrometry and test identified functional interactions by generating knockouts in organoids. The central hypothesis is that commensal viruses establish unique molecular interactions with the respiratory epithelium that enable persistence and modulate immune homeostasis; understanding these dynamics will inform factors influencing host immunity, disease susceptibility, and therapeutic response. Performance runs from September 1, 2026, through August 31, 2028, with work conducted in San Francisco, California. This is a Project Grant assistance type.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $378.0k | 9/1/26 |