Project Grant R03DE036044
- The National Institute of Dental and Craniofacial Research awarded The Children's Hospital Corporation, doing business as Boston Children's Hospital, $539,217 on September 3, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the microbiology of dentin invasion in dental caries. The project addresses how cariogenic microbes invade dentin—the tooth structure beneath enamel—and reach the pulp, causing toothaches, periapical inflammation, abscess, and systemic...
- The National Institute of Dental and Craniofacial Research awarded The Trustees of Columbia University in the City of New York $152,166 on September 4, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to conduct research on blastema-driven craniofacial regeneration in zebrafish. The research investigates how multiple blastemas—regenerative cell clusters—coordinate to restore craniofacial joint tissues following injury. The project uses an adult zebrafish whole joint...
- The National Institute of Dental and Craniofacial Research, part of the Department of Health and Human Services National Institutes of Health, awarded the University of Illinois $249,000 on August 5, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop bone-like organoids that elucidate how immune responses influence craniofacial bone healing and regeneration. The recipient will establish bone-like organoids as predictive tools for craniofacial bone repair...
- The National Institute of Dental and Craniofacial Research awarded Trustees of Boston University $249,000 on May 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate neutrophil-sensory neuron interactions in dental pulp inflammation and pain. The research addresses pulpitis, an inflammatory disease of the dental pulp currently managed through invasive procedures such as root canal therapy and tooth extraction. The project examines how neutrophils drive...
- The National Institute of Dental and Craniofacial Research awarded the Stowers Institute For Medical Research $371,250 on March 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the pathogenesis, phenotypic variation, and prevention of craniofacial anomalies. The project examines how genetic and environmental factors interact to produce craniofacial birth defects—conditions such as cleft lip and palate, micrognathia, and craniosynostosis that account...
- The National Institute of Dental and Craniofacial Research awarded $597,769 to the Trustees of Columbia University in the City of New York on August 3, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121, a Project Grant). The award funds development of an engineered hydrogel-patient-derived organoid platform with tunable viscoelastic properties designed to model oral epithelial dysplasia and recapitulate the biomechanics of dysplasia and oral squamous cell carcinoma...
- The National Institute of Dental and Craniofacial Research, part of the Department of Health and Human Services National Institutes of Health, awarded $151,590 to The Johns Hopkins University on February 18, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to support research determining the role of RAFTLIN-2 in neural crest cell specification and migration. The research investigates how RAFTLIN-2, a gene upregulated during cranial neural crest cell specification,...
- The National Institute of Dental and Craniofacial Research awarded the Stowers Institute for Medical Research $124,200 on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate ribosome biogenesis regulation of neural crest cell differentiation in development and disease. The funded research examines how ribosomal RNA transcription and ribosome biogenesis control neural crest cell fate acquisition and differentiation during craniofacial...
- The National Institute of Dental and Craniofacial Research awarded Virginia Commonwealth University $310,500 on June 15, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the role of nuclear bone morphogenetic protein 2 (NBMP2) in macrophage-mediated periodontal regeneration and bone repair. The research will characterize the regulation of macrophage NBMP2 and BMP2 expression, functionally dissect NBMP2-regulated STAT6 signaling pathways in macrophages,...
- This $672,394.58 project grant from the National Institutes of Health's National Institute of Dental and Craniofacial Research Oral Diseases and Disorders Research program (CFDA 93.121) supports the development of a crosslinkable tissue particle implant for regenerating craniofacial bone. Led by Leefa Biotech LLC, the one-year award aims to demonstrate improved bone regeneration in critical-size cranial bone defects using the implant compared to the current standard of care. If successful, the...
The National Institute of Dental and Craniofacial Research awarded Trustees of Boston College $310,000 on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to engineer controlled degradation of decellularized plant scaffolds for hard tissue engineering applications. Boston College will develop ultrasound-responsive, cellulase-encapsulated poly(lactic-co-glycolic acid) microbubbles for remote-controlled release of degradative enzymes into decellularized lucky bamboo scaffolds, enabling tunable breakdown of plant cellulose structures to match cell growth and tissue regeneration rates. The work includes designing degradation strategies via three specific aims and implementing artificial intelligence and machine learning-driven, image-guided monitoring of degradation profiles to enhance the quality of regenerated bone tissue. The project addresses a core challenge in plant scaffold–based craniofacial reconstruction: the absence of human cellulases to degrade plant structures naturally, which has limited adoption of plant-derived scaffolds despite their scalability, cost advantages, and structural similarity to native extracellular matrices. Performance occurs in Chestnut Hill, Newton, Massachusetts. The period of performance runs from September 1, 2026, through August 31, 2028. This is a Project Grant, the assistance type used by NIDCR for extramural research supporting basic, translational, and clinical research in dental, oral, and craniofacial health.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $310.0k | 9/1/26 |