Project Grant R03DE034666
- This $645,034 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, supports a research project titled "LEVERAGING WHOLE GENOME SEQUENCING AND FUNCTIONAL GENOMIC CHARACTERIZATION TO IMPROVE NSCLP GENE DISCOVERY." The project aims to integrate genomic data, including whole genome sequencing and polygenic risk scores, to systematically evaluate and validate the contributions of...
- The University of Missouri at Kansas City (UMKC) received a $313,000 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The purpose of this 2-year grant, running from July 1, 2025 to June 30, 2027, is to conduct a secondary analysis of whole genome sequencing data from the Gabriella Miller Kids First Orofacial Cleft cohorts to identify genetic variants that impact regulatory elements...
- This $295,856 Project Grant awarded by the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), aims to identify rare genetic variants associated with orofacial clefts (OFCs). The two key objectives are: (1) identifying craniofacial genes with rare deleterious variants, and (2) identifying craniofacial enhancers with rare deleterious variants. By pinpointing these rare variants, the project seeks to...
- This Project Grant award, provided by the National Institute of Dental and Craniofacial Research (NIDCR), supports research under the Oral Diseases and Disorders Research program (CFDA 93.121) on the role of primary cilia and the C2CD3 protein in craniofacial skeletal development. The $646,212 award to the Children's Hospital Medical Center in Cincinnati, Ohio will fund experiments to determine if skeletal differentiation is impaired in human induced pluripotent stem cell-derived neural crest...
- This federal Project Grant award of $1,608,956.00 was provided by the National Institute of Dental and Craniofacial Research (NIDCR), which administers the Oral Diseases and Disorders Research program (CFDA 93.121). The grant aims to generate a single-cell multimodal atlas of human craniofacial development and conduct evolution-driven computational and experimental studies of enhancers involved in human midface development. This research is intended to improve understanding of the genetic...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $390,000 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to The Medical College of Wisconsin, Inc. The grant funds a 5-year research project to leverage single-cell co-culture and gene expression profiling to identify tumor antigen-specific T cells in oral squamous cell carcinoma (OSCC). The project aims to develop innovative methods to isolate and characterize tumor-infiltrating...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $1,281,274 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to Seattle Children's Hospital, doing business as Seattle Children's Research Institute. The grant, titled "Leveraging Advances in Practices and Outcomes in Cleft Care: The LEAP Study", aims to create an inclusive global collaborative to develop a cleft-focused learning health system. The project will focus on the...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $673,091 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program to the University of Pittsburgh. The grant, which runs from August 14, 2025 to May 31, 2028, aims to advance the genomics knowledge base for oral diseases, focusing on dental caries and periodontitis. Key activities include performing the largest genome-wide association scans of these conditions, developing...
- This Project Grant award of $889,616.00 from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) supports research to investigate the cellular and molecular mechanisms by which specific RNAs and proteins enriched in neural crest cell (NCC) protrusions promote NCC migration. The research aims to determine the transcriptome and proteome of NCC projections and test their function, as well as examine the localization...
- This Project Grant award, totaling $493,458, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program. The grant aims to investigate the role of ARID1 proteins in regulating cranial neural crest cell (CNCC) development, which is critical for proper craniofacial formation. The project will examine how ARID1A and ARID1B, subunits of the chromatin remodeling complex BAF, dynamically...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $320,000 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to Marshfield Clinic, Inc. The project aims to identify genomic regulatory elements involved in the development of oral clefts, a common birth defect. Specifically, the research will 1) identify enhancers that drive gene expression in human embryonic palatal mesenchyme cells, 2) determine which enhancers regulate transcription specifically within these cells, and 3) confirm the palate-specificity of selected enhancers through in vitro assays. This research is intended to advance the fundamental understanding of the molecular pathways controlling lip and palate development, which could lead to improved prevention, early detection, and treatment strategies for oral clefts.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $320.0k | 8/13/25 |