Project Grant R03AG101241
- Federal Grant Award Summary The National Institute on Aging awarded The Washington University a Project Grant in the amount of $556,121 under the Aging Research program (CFDA 93.866) on January 15, 2026. The award supports research through December 31, 2030, conducted at the university's St. Louis, Missouri facility. The project investigates transgenerational epigenetic adaptation and longevity changes in response to repeated environmental stresses, utilizing Caenorhabditis elegans (C....
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of Texas at Arlington $472,793 under the Aging Research program (CFDA 93.866) for a three-year project period running from September 1, 2025 through August 31, 2028. This Project Grant supports research to decouple reproductive aging from somatic aging by investigating the role of the mammalian target of rapamycin complex 2 (mTORC2) pathway, specifically the SGK-1 kinase component, in reproductive...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded Columbia University's Health Sciences Division a Project Grant of $149,190 on August 6, 2026, under the Aging Research program (CFDA 93.866) to conduct biomedical research on the mechanisms of NBR2, a long non-coding ribonucleic acid (RNA), in human ovarian aging. The research directly addresses the NIA's mission to support investigation of age-related diseases and conditions affecting women's health, responding...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of Massachusetts Medical School a Project Grant totaling $452,783 (Award Date: June 1, 2026; Completion Date: May 31, 2028) under the Aging Research program (CFDA 93.866) to conduct biomedical research on the molecular mechanisms of neuronal cell death and neurodegeneration. The primary research deliverables include investigation of how context-specific molecular pathways protect against age-related...
- Federal Project Grant Award Summary The University of California, San Diego received a $439,750 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) for the period May 1, 2026 through April 30, 2028. This award funds research investigating the molecular mechanisms of nucleophagy—the autophagic degradation of nuclear envelope regions—and its relationship to chronological aging. The research will employ genetic screening, biochemical analysis, and...
- Federal Project Grant Award Summary The University of Virginia received a $522,167 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded August 1, 2025, with a completion date of May 31, 2030. This research project investigates the mechanisms of ribosomal DNA (rDNA) instability during aging, with a focus on understanding how DNA double-strand breaks and genomic instability contribute to cellular aging. The research examines the roles of FOB1 and its...
- Federal Grant Award Summary The University of Michigan received a $2.99 million Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective September 1, 2025, through August 31, 2029. This award supports biomedical research investigating reactive oxygen species (ROS) as early-life modulators of lifespan and age-related disease development. The research employs a multipronged approach utilizing model organisms—including Caenorhabditis elegans...
- Federal Grant Award Summary The University of Pittsburgh received a $453,785 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) for the period May 1, 2026 through April 30, 2028. This exploratory research project investigates the conserved functional role of TCERG1 (Transcription Elongation and RNA Capping Related Gene 1), a mammalian homolog of the C. elegans protein TCER-1, in regulating fertility and reproductive aging. The research will generate...
- Federal Grant Award Summary The National Institute on Aging awarded Rutgers, The State University a $909,876 Project Grant on August 15, 2025, under the Aging Research program (CFDA 93.866) to investigate the molecular mechanisms by which exercise protects the aging nervous system. The research utilizes Caenorhabditis elegans (C. elegans) as a model organism to understand how regular physical activity extends longevity, maintains nervous system functionality in aging, and provides...
- Federal Grant Award Summary The Buck Institute for Research on Aging received a $809,486 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective February 1, 2026, through January 31, 2031. This award supports research investigating the role of Oxidation Resistance 1 (OXR1) and retromer proteins in brain aging and Alzheimer's disease and related dementias (ADRD). The research leverages both Drosophila melanogaster (fruit fly) models...
The University of New Orleans received a $149,000 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective May 1, 2026, through April 30, 2028. This biomedical research project investigates the mechanistic links between elevated reproductive activity and reduced lifespan using the model organism Caenorhabditis elegans with hyperactive germlines. The primary deliverable is scientific research designed to identify somatic transcriptional targets of germline-derived hedgehog signaling that mediate lifespan shortening, with particular emphasis on understanding how germline hyperactivity influences lipid metabolism and whether mating-induced fat loss represents passive resource reallocation or active lipid-based signaling between germline and soma. The research outputs are expected to advance fundamental knowledge of the conserved reproduction-longevity trade-off observed across animal species, with potential implications for understanding lipid metabolism, germline-soma communication, fertility maintenance, and lifespan extension mechanisms applicable to humans. The project addresses a critical gap in aging research by examining how increased reproduction influences somatic aging, moving beyond prior studies that focused on germline removal or limited reproductive capacity. Results from this two-year investigation will contribute to the broader NIA mission of supporting biomedical and behavioral research directed toward understanding the aging process and age-related diseases.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $149.0k | 5/5/26 |