Project Grant R03AG097670
- The National Institute on Aging awarded the University of Miami $3.73 million on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop and internally validate predictive markers and a composite risk score for phenoconversion to clinically manifest amyotrophic lateral sclerosis (ALS) or frontotemporal dementia (FTD) in C9ORF72 repeat expansion carriers. The award funds evaluation of leading clinical markers and biomarkers—including presence of prodromal syndrome, thalamic...
- The National Institute on Aging awarded $526,607 to Wake Forest University on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop computational imaging frameworks that integrate neuroimaging with multi-omics data to identify Alzheimer's disease subtypes and model neurodegenerative progression with calibrated uncertainty. The project, titled "Neuroimaging Multi-Omics Fingerprints for Subtyping and Uncertainty-Aware Prediction of Alzheimer's Disease," will...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded The Leland Stanford Junior University $682,281 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop a human induced pluripotent stem cell-based three-dimensional brain tissue microsphere model that recapitulates granulin deficiency phenotypes and associated pathology in neurodegenerative diseases including frontotemporal dementia and neuronal ceroid lipofuscinosis. The model...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded the University of California, Los Angeles $146,750 under the Aging Research program (CFDA 93.866) on July 1, 2026, to identify molecular-neuropathological signatures in Alzheimer's disease, frontotemporal lobar degeneration, and long COVID. The recipient will employ single-cell spatial multi-omics on postmortem brain tissues to characterize molecular and cellular alterations linked to selective...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded Thomas Jefferson University $429,000 on September 1, 2026, under the Aging Research program (CFDA 93.866) to characterize neurodegenerative hallmarks in induced neural stem cells (iNSCs) derived from patient fibroblasts to study dsRNA-mediated inflammation in C9ORF72-associated ALS and frontotemporal dementia. The research employs a novel disease model using age-preserved iNSCs directly...
- The National Institute on Aging awarded Trustees of Indiana University (doing business as Indiana University Indianapolis) $791,039 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop computational methods enabling patient-centered prognostic profiling for Alzheimer's disease and related dementias that accounts for individual cognitive resilience in response to neuropathological changes. The work will model each patient's distinct connectome architecture and cognitive...
- The National Institute on Aging awarded Drexel University $420,554 under Aging Research (CFDA 93.866) on September 1, 2026, to establish an integrated system for studying senescence and aging in the central nervous system. The award funds two research aims: characterization of the molecular and functional consequences of senescence in astrocyte and neuronal cultures, and evaluation of senescence impact in a multicellular context using hiPSC-derived vascularized cortical organoids. Single-cell...
- The National Institute on Aging, a component of the Department of Health and Human Services, awarded Massachusetts Institute of Technology $596,050 on September 15, 2026, under the Aging Research program (CFDA 93.866) to investigate fuzzy coat dynamics of post-translationally modified tau aggregation. The project examines structural properties of tau, a microtubule-associated protein whose aggregation hallmarks Alzheimer's disease and twenty other neurodegenerative diseases. The research tests...
- The National Institute on Aging awarded University of Massachusetts Medical School $445,130 on January 1, 2026, under the Aging Research program (CFDA 93.866) to support research elucidating the mechanisms by which MS4A genes regulate neurodegeneration in Alzheimer's disease and related disorders. The research investigates how genetic deletion and polymorphisms of MS4A family genes—particularly MS4A6C, MS4A4A, MS4A4E, and MS4A6E—affect disease progression across multiple neurodegenerative...
- The National Institute on Aging awarded the J. David Gladstone Institutes $1,731,105 on February 15, 2026, under the Aging Research program (CFDA 93.866) to conduct genetic dissection of the 17Q21.31 MAPT locus in neurodegenerative disease. The research will identify genetic drivers of disease risk within the MAPT locus, a chromosomal region associated with Alzheimer's disease, six or more other neurodegenerative diseases, and multiple neurodevelopmental and non-brain diseases. The locus...
The National Institute on Aging awarded the National Institute of Mental Health and Neuro Sciences $215,961 on September 1, 2026, under the Aging Research program (CFDA 93.866) to establish and characterize a cohort of 300 presymptomatic family members of frontotemporal dementia patients in India through deep phenotyping, genetic profiling, serum biomarkers, and advanced brain imaging. The work aims to identify early indicators of disease progression in presymptomatic relatives carrying mutations in C9ORF72, GRN, and MAPT genes, stratify individuals by genetic risk and presymptomatic status, and enhance clinical trial readiness for targeted therapies and biomarker-driven interventions in a population underrepresented in frontotemporal lobar degeneration research. Place of performance is India, with a project period from September 1, 2026, through August 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $216.0k | 8/27/26 |